Uri1 URI1, prefoldin-like chaperone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uri1provided by MGI
Official Full Name: URI1, prefoldin-like chaperoneprovided by MGI
Primary source: MGI:MGI:1342294
See related: Ensembl:ENSMUSG00000030421 AllianceGenome:MGI:1342294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rmp; NNX3
Summary: Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of phosphatase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Is expressed in several structures, including alimentary system; brain; epithelium; genitourinary system; and muscle tissue. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 10.9), bladder adult (RPKM 10.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 25.29 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (37659417..37722989, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (37959992..38023564, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coxsackievirus B Type 4 Infection in beta Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
Title: Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
RMP plays a protective role in chronic heart failure, protecting cardiomyocytes from injury by maintaining PGC1alpha-dependent mitochondrial biogenesis and function.
Title: Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure.
Results show that RMP serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 transcription.
Title: RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription.
Results show that URI expression is essential for hepatocarcinogenesis and associated with poor survival.
Title: Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C80913 (e-PCR), detects polymorphism
- UniSTS:532480

AF091096 (e-PCR)
- UniSTS:185706

RH126498 (e-PCR)
- UniSTS:163206

C80913 (e-PCR), detects polymorphism
- UniSTS:159631

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to steroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to steroid hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RPAP3/R2TP/prefoldin-like complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: unconventional prefoldin RPB5 interactor

Names: RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; protein phosphatase 1 regulatory subunit 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417201.1 → NP_001404130.1 unconventional prefoldin RPB5 interactor isoform b

Status: VALIDATED

Source sequence(s)

AC163447

UniProtKB/TrEMBL

A0A0U1RPG9
NM_001417202.1 → NP_001404131.1 unconventional prefoldin RPB5 interactor isoform b

Status: VALIDATED

Source sequence(s)

AC163447

UniProtKB/TrEMBL

A0A0U1RPG9
NM_011274.6 → NP_035404.4 unconventional prefoldin RPB5 interactor isoform a

See identical proteins and their annotated locations for NP_035404.4

Status: VALIDATED

Source sequence(s)

AC163447

Consensus CDS

CCDS21157.1

UniProtKB/Swiss-Prot

Q3TLD5, Q3V078, Q8R5C4, Q9Z243

UniProtKB/TrEMBL

A0A0U1RPG9

Related

ENSMUSP00000082646.5, ENSMUST00000085513.6

Conserved Domains (1) summary

cl09111
Location:36 → 145

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

37659417..37722989 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539676.3 → XP_006539739.2 unconventional prefoldin RPB5 interactor isoform X1

UniProtKB/TrEMBL

A0A0U1RNX4

Related

ENSMUSP00000145738.2, ENSMUST00000206581.2

Conserved Domains (1) summary

cl09111
Location:48 → 150

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
XM_006539677.4 → XP_006539740.1 unconventional prefoldin RPB5 interactor isoform X2

UniProtKB/TrEMBL

A0A0U1RPG9

Conserved Domains (1) summary

cl09111
Location:8 → 99

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...