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    Pde7a phosphodiesterase 7A [ Mus musculus (house mouse) ]

    Gene ID: 18583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde7aprovided by MGI
    Official Full Name
    phosphodiesterase 7Aprovided by MGI
    Primary source
    MGI:MGI:1202402
    See related
    Ensembl:ENSMUSG00000069094 AllianceGenome:MGI:1202402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in cAMP-mediated signaling. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.8), whole brain E14.5 (RPKM 10.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde7a in Genome Data Viewer
    Location:
    3 A2; 3 5.36 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19277272..19365486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19223108..19311322, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E334 Neighboring gene STARR-positive B cell enhancer ABC_E3427 Neighboring gene mitochondrial fission regulator 1 Neighboring gene STARR-seq mESC enhancer starr_07090 Neighboring gene STARR-seq mESC enhancer starr_07091 Neighboring gene RIKEN cDNA 3110037C07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:19250042-19250343 Neighboring gene predicted gene, 52602 Neighboring gene predicted gene, 42188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice. Liu Z, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2023 Jan 10. PMID 36220621
    2. Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells. Goto M, et al. Cell Immunol, 2009. PMID 19477436
    3. ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice. Kadoshima-Yamaoka K, et al. Eur J Pharmacol, 2009 Jun 24. PMID 19379723
    4. Cloning, characterization, and tissue distribution of mouse phosphodiesterase 7A1. Wang P, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027622
    5. Phosphodiesterase 7A-deficient mice have functional T cells. Yang G, et al. J Immunol, 2003 Dec 15. PMID 14662840

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
      Title: Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
    2. Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice.
      Title: Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice.
    3. PDE7 has roles in regulating oligodendrocyte precursor survival and differentiation during brain development and in adulthood
      Title: Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival.
    4. PDE7A is involved in regulation of cell proliferation and cytokine production of NKT cells.
      Title: Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
    5. results demonstrate that PDE7A might regulate TNF-alpha production in keratinocytes in a cAMP-dependent fashion
      Title: ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice.
    6. PDE7A is not essential for activation of T lymphocytes; its inactivation by targeted gene disruption appears to enhance in vivo humoral immune responses.
      Title: Phosphodiesterase 7A-deficient mice have functional T cells.
    7. The roles PDE7A1 and its regulatory region play in cAMP signaling were examined by studying interactions with PKA subunits.
      Title: PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    high affinity 3',5'-cyclic-AMP phosphodiesterase 7A
    Names
    cAMP-specific phosphodiesterase 7A
    high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
    NP_001116231.1
    NP_032828.2
    XP_006535468.1
    XP_006535469.1
    XP_006535471.1
    XP_030108316.1
    XP_036018817.1
    XP_036018818.1
    XP_036018819.1
    XP_036018820.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122759.3 → NP_001116231.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 2

      See identical proteins and their annotated locations for NP_001116231.1

      Status: VALIDATED

      Source sequence(s)
      AC102756, AC127283
      Consensus CDS
      CCDS50871.1
      UniProtKB/TrEMBL
      Q3U3Y7, Q6P5G2
      Related
      ENSMUSP00000096800.4, ENSMUST00000099195.10
      Conserved Domains (2) summary
      pfam00233
      Location:211 → 431
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam09195
      Location:51 → 128
      Endonuc-BglII; Restriction endonuclease BglII

    2. NM_001428503.1 → NP_001415432.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102756, AC127283
      UniProtKB/TrEMBL
      Q6P5G2

    3. NM_008802.4 → NP_032828.2  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 1

      See identical proteins and their annotated locations for NP_032828.2

      Status: VALIDATED

      Source sequence(s)
      AC127283
      Consensus CDS
      CCDS38398.1
      UniProtKB/Swiss-Prot
      P70453, Q3TFY5, Q9ERB3
      UniProtKB/TrEMBL
      Q6P5G2
      Related
      ENSMUSP00000088863.5, ENSMUST00000091314.11
      Conserved Domains (2) summary
      pfam00233
      Location:185 → 405
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam09195
      Location:16 → 102
      Endonuc-BglII; Restriction endonuclease BglII

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      19277272..19365486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162924.1 → XP_036018817.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

      Conserved Domains (1) summary
      pfam00233
      Location:65 → 285
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_036162925.1 → XP_036018818.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

      Conserved Domains (1) summary
      pfam00233
      Location:65 → 285
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_006535405.4 → XP_006535468.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X1

      UniProtKB/TrEMBL
      Q6P5G2
      Conserved Domains (1) summary
      pfam00233
      Location:206 → 426
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_006535408.5 → XP_006535471.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

      Conserved Domains (1) summary
      pfam00233
      Location:21 → 241
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_036162926.1 → XP_036018819.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

      Conserved Domains (1) summary
      pfam00233
      Location:65 → 285
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. XM_036162927.1 → XP_036018820.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

      Conserved Domains (1) summary
      pfam00233
      Location:21 → 241
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    7. XM_030252456.2 → XP_030108316.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

      Conserved Domains (1) summary
      pfam00233
      Location:21 → 241
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. XM_006535406.5 → XP_006535469.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X2

      Conserved Domains (1) summary
      pfam00233
      Location:183 → 403
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RNA

    1. XR_004941293.1 RNA Sequence

    2. XR_389588.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70453.2 GenPept UniProtKB/Swiss-Prot:P70453

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