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    Spink13 serine peptidase inhibitor, Kazal type 13 [ Mus musculus (house mouse) ]

    Gene ID: 100038417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spink13provided by MGI
    Official Full Name
    serine peptidase inhibitor, Kazal type 13provided by MGI
    Primary source
    MGI:MGI:3642511
    See related
    Ensembl:ENSMUSG00000073551 AllianceGenome:MGI:3642511
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm10534; Spink5l3
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of acrosome reaction. Predicted to be located in extracellular region. Orthologous to human SPINK13 (serine peptidase inhibitor Kazal type 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 1.5) and testis adult (RPKM 0.1) See more
    Orthologs
    human all
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    Genomic context

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    See Spink13 in Genome Data Viewer
    Location:
    18 E1; 18 35.37 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62740570..62874458, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62607499..62741387, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene F-box protein 38 Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide pseudogene Neighboring gene STARR-seq mESC enhancer starr_44778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:62879723-62879876 Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598 Neighboring gene STARR-seq mESC enhancer starr_44779 Neighboring gene STARR-seq mESC enhancer starr_44780 Neighboring gene predicted gene, 41752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility. Ma L, et al. J Biol Chem, 2013 Apr 5. PMID 23430248, Free PMC Article
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility
      Title: Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of acrosome reaction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 13
    Names
    serine protease inhibitor Kazal-type 5-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168423.2 → NP_001161895.1  serine protease inhibitor Kazal-type 13 precursor

      See identical proteins and their annotated locations for NP_001161895.1

      Status: PROVISIONAL

      Source sequence(s)
      AK139149
      Consensus CDS
      CCDS50305.1
      UniProtKB/Swiss-Prot
      Q3UTS8
      Related
      ENSMUSP00000095165.4, ENSMUST00000097557.5
      Conserved Domains (1) summary
      smart00280
      Location:55 → 96
      KAZAL; Kazal type serine protease inhibitors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      62740570..62874458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525460.4 → XP_006525523.2  serine protease inhibitor Kazal-type 13 isoform X1

      Conserved Domains (1) summary
      smart00280
      Location:95 → 136
      KAZAL; Kazal type serine protease inhibitors

    2. XM_030250229.2 → XP_030106089.1  serine protease inhibitor Kazal-type 13 isoform X2

      UniProtKB/Swiss-Prot
      Q3UTS8
      Conserved Domains (1) summary
      smart00280
      Location:55 → 96
      KAZAL; Kazal type serine protease inhibitors

    3. XM_030250228.2 → XP_030106088.1  serine protease inhibitor Kazal-type 13 isoform X2

      UniProtKB/Swiss-Prot
      Q3UTS8
      Related
      ENSMUSP00000157623.2, ENSMUST00000235190.2
      Conserved Domains (1) summary
      smart00280
      Location:55 → 96
      KAZAL; Kazal type serine protease inhibitors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UTS8.1 GenPept UniProtKB/Swiss-Prot:Q3UTS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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