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    Cym chymosin [ Mus musculus (house mouse) ]

    Gene ID: 229697, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cymprovided by MGI
    Official Full Name
    chymosinprovided by MGI
    Primary source
    MGI:MGI:2684977
    See related
    Ensembl:ENSMUSG00000046213 AllianceGenome:MGI:2684977
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm131
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in stomach fundus epithelium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 16.9), duodenum adult (RPKM 11.6) and 2 other tissues See more
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    Genomic context

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    See Cym in Genome Data Viewer
    Location:
    3 F2.3; 3 46.68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107118611..107129048, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107211295..107221732, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 2 Neighboring gene STARR-seq mESC enhancer starr_08660 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10 Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene prokineticin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:107081789-107082089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. Sayols S, et al. Development, 2020 Sep 15. PMID 32878924
    2. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. Chang I, et al. J Clin Invest, 2013 Jun. PMID 23676500, Free PMC Article
    3. Id2 Determines Intestinal Identity through Repression of the Foregut Transcription Factor Irx5. Mori K, et al. Mol Cell Biol, 2018 May 1. PMID 29463648, Free PMC Article
    4. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    embryonic pepsinogen
    NP_001104613.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111143.1 → NP_001104613.1  embryonic pepsinogen precursor

      See identical proteins and their annotated locations for NP_001104613.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132405
      Consensus CDS
      CCDS51041.1
      UniProtKB/TrEMBL
      B7ZWD6
      Related
      ENSMUSP00000029504.9, ENSMUST00000029504.9
      Conserved Domains (3) summary
      pfam00026
      Location:73 → 378
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:19 → 44
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:64 → 377
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107118611..107129048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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