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    LRRC73 leucine rich repeat containing 73 [ Homo sapiens (human) ]

    Gene ID: 221424, updated on 27-Nov-2024

    Summary

    Official Symbol
    LRRC73provided by HGNC
    Official Full Name
    leucine rich repeat containing 73provided by HGNC
    Primary source
    HGNC:HGNC:21375
    See related
    Ensembl:ENSG00000204052 AllianceGenome:HGNC:21375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf154
    Expression
    Biased expression in testis (RPKM 12.8), brain (RPKM 2.3) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LRRC73 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43506968..43510346, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43335707..43339085, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43474706..43478084, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1113, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43445658-43446451 Neighboring gene tight junction associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43457381-43457974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43457975-43458569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24602 Neighboring gene Yip1 domain family member 3 Neighboring gene RNA polymerase I and III subunit C Neighboring gene MPRA-validated peak5815 silencer Neighboring gene exportin 5 Neighboring gene ribosomal protein S2 pseudogene 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 73

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012974.4NP_001012992.1  leucine-rich repeat-containing protein 73 isoform 1

      See identical proteins and their annotated locations for NP_001012992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL355802
      Consensus CDS
      CCDS34456.1
      UniProtKB/Swiss-Prot
      Q5JTD7
      Related
      ENSP00000361518.1, ENST00000372441.2
      Conserved Domains (2) summary
      sd00033
      Location:5886
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:5255
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_001271882.2NP_001258811.1  leucine-rich repeat-containing protein 73 isoform 2

      See identical proteins and their annotated locations for NP_001258811.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL355802, BC107130, BC108661, HY024930
      UniProtKB/TrEMBL
      Q3B825
      Conserved Domains (1) summary
      cl39015
      Location:19132
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43506968..43510346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      43335707..43339085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)