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    GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type [ Homo sapiens (human) ]

    Gene ID: 9245, updated on 27-Nov-2024

    Summary

    Official Symbol
    GCNT3provided by HGNC
    Official Full Name
    glucosaminyl (N-acetyl) transferase 3, mucin typeprovided by HGNC
    Primary source
    HGNC:HGNC:4205
    See related
    Ensembl:ENSG00000140297 MIM:606836; AllianceGenome:HGNC:4205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GNTM; C24GNT; C2GNT2; C2GNTM; C2/4GnT
    Summary
    This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
    Expression
    Biased expression in colon (RPKM 74.9), small intestine (RPKM 64.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GCNT3 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59611783..59622723)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57413480..57424422)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59903982..59914922)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 117 Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:59908775-59909010 Neighboring gene general transcription factor IIA subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9499 Neighboring gene BCL2 interacting protein 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of glucosaminyl (N-acetyl) transferase 3, mucin type (GCNT3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    General protein information

    Preferred Names
    beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
    Names
    C2GnT-mucin type
    beta1,6-N-acetylglucosaminyltransferase-M
    beta1,6GlcNAc-transferase
    core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase
    hC2GnT-M
    mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
    NP_001413591.1
    NP_004742.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426662.1NP_001413591.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      CP068263
    2. NM_004751.3NP_004742.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 isoform 1

      See identical proteins and their annotated locations for NP_004742.1

      Status: REVIEWED

      Source sequence(s)
      AC092755, BC017032, BP243086
      Consensus CDS
      CCDS10172.1
      UniProtKB/Swiss-Prot
      O95395
      UniProtKB/TrEMBL
      B2R758
      Related
      ENSP00000379377.1, ENST00000396065.3
      Conserved Domains (1) summary
      pfam02485
      Location:133401
      Branch; Core-2/I-Branching enzyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      59611783..59622723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      57413480..57424422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)