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    WNT5B Wnt family member 5B [ Homo sapiens (human) ]

    Gene ID: 81029, updated on 9-Dec-2024

    Summary

    Official Symbol
    WNT5Bprovided by HGNC
    Official Full Name
    Wnt family member 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:16265
    See related
    Ensembl:ENSG00000111186 MIM:606361; AllianceGenome:HGNC:16265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in prostate (RPKM 12.1), esophagus (RPKM 5.6) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WNT5B in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (1617056..1647212)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (1612578..1643573)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1726222..1756378)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5803 Neighboring gene F-box and leucine rich repeat protein 14 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:1697008-1697667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1701701-1702304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1715019-1715538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1714497-1715018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4116 Neighboring gene Sharpr-MPRA regulatory region 3814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1755758-1756258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1756259-1756759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5809 Neighboring gene microRNA 3649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1800052-1800630 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene adiponectin receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2648

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chondrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fat cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lens fiber cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of convergent extension involved in gastrulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein Wnt-5b
    Names
    WNT-5B protein
    wingless-type MMTV integration site family, member 5B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030775.2NP_110402.2  protein Wnt-5b precursor

      See identical proteins and their annotated locations for NP_110402.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs from variant 1 in the 5' UTR, which results from an alternate exon. Both variants encode the same protein.
      Source sequence(s)
      AY009399
      Consensus CDS
      CCDS8510.1
      UniProtKB/Swiss-Prot
      A8K315, D3DUP9, Q96S49, Q9BV04, Q9H1J7
      Related
      ENSP00000308887.3, ENST00000310594.7
      Conserved Domains (1) summary
      pfam00110
      Location:50359
      wnt; wnt family
    2. NM_032642.3NP_116031.1  protein Wnt-5b precursor

      See identical proteins and their annotated locations for NP_116031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs from variant 2 in the 5' UTR, which results from an alternate exon. Both variants encode the same protein.
      Source sequence(s)
      AC005182
      Consensus CDS
      CCDS8510.1
      UniProtKB/Swiss-Prot
      A8K315, D3DUP9, Q96S49, Q9BV04, Q9H1J7
      Related
      ENSP00000380379.2, ENST00000397196.7
      Conserved Domains (1) summary
      pfam00110
      Location:50359
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      1617056..1647212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      1612578..1643573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)