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    TRIM66 tripartite motif containing 66 [ Homo sapiens (human) ]

    Gene ID: 9866, updated on 3-Dec-2024

    Summary

    Official Symbol
    TRIM66provided by HGNC
    Official Full Name
    tripartite motif containing 66provided by HGNC
    Primary source
    HGNC:HGNC:29005
    See related
    Ensembl:ENSG00000166436 MIM:612000; AllianceGenome:HGNC:29005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIF1D; C11orf29; TIF1DELTA
    Summary
    Predicted to enable chromatin binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 4.5), skin (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM66 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8612040..8683231, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8693787..8764985, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8633587..8704778, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8271693-8272438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8272439-8273182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8281879-8282380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8283311-8283850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8288990-8289574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8289575-8290158 Neighboring gene MPRA-validated peak1191 silencer Neighboring gene LIM domain only 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8303849-8304410 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:8304411-8304972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8339910-8340410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8347375-8347960 Neighboring gene Sharpr-MPRA regulatory region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8358075-8358892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8359711-8360526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8360626-8361287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8373273-8373772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4384 Neighboring gene serine/threonine kinase 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4385 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3114 Neighboring gene NANOG hESC enhancer GRCh37_chr11:8625413-8625914 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:8692389-8692996 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:8703769-8704968 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27a

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of tripartite motif containing 66 (TRIM66) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10046

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tripartite motif-containing protein 66
    Names
    transcriptional intermediary factor 1 delta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388022.1NP_001374951.1  tripartite motif-containing protein 66 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      Consensus CDS
      CCDS91432.1
      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Related
      ENSP00000495413.1, ENST00000646038.2
      Conserved Domains (5) summary
      cd05502
      Location:12181326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11451193
      PHD_SF; PHD finger superfamily
    2. NM_001388023.1NP_001374952.1  tripartite motif-containing protein 66 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      Consensus CDS
      CCDS91433.1
      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A994J572
      Related
      ENSP00000516162.1, ENST00000705689.1
      Conserved Domains (5) summary
      cd05502
      Location:11811289
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:216341
      BBC; B-Box C-terminal domain
      cd19794
      Location:171213
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:112148
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11081156
      PHD_SF; PHD finger superfamily
    3. NM_001388024.1NP_001374953.1  tripartite motif-containing protein 66 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (6) summary
      cd05502
      Location:11901298
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      TIGR00601
      Location:710909
      rad23; UV excision repair protein Rad23
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11171165
      PHD_SF; PHD finger superfamily
    4. NM_014818.2NP_055633.1  tripartite motif-containing protein 66 isoform 1

      See identical proteins and their annotated locations for NP_055633.1

      Status: VALIDATED

      Source sequence(s)
      AC091053, AC104360
      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:10421150
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:9691017
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      8612040..8683231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018629.2XP_016874118.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Conserved Domains (5) summary
      cd05502
      Location:12181326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11451193
      PHD_SF; PHD finger superfamily
    2. XM_047427941.1XP_047283897.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    3. XM_011520507.4XP_011518809.1  tripartite motif-containing protein 66 isoform X1

      See identical proteins and their annotated locations for XP_011518809.1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Conserved Domains (5) summary
      cd05502
      Location:12181326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11451193
      PHD_SF; PHD finger superfamily
    4. XM_047427943.1XP_047283899.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    5. XM_011520510.2XP_011518812.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (6) summary
      cd05502
      Location:11901298
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      TIGR00601
      Location:710909
      rad23; UV excision repair protein Rad23
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11171165
      PHD_SF; PHD finger superfamily
    6. XM_011520509.2XP_011518811.1  tripartite motif-containing protein 66 isoform X3

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (4) summary
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd00021
      Location:209244
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl02556
      Location:12251301
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl22851
      Location:11451193
      PHD_SF; PHD finger superfamily
    7. XM_011520508.3XP_011518810.1  tripartite motif-containing protein 66 isoform X2

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      Conserved Domains (6) summary
      cd05502
      Location:12181326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      pfam05109
      Location:722894
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11451193
      PHD_SF; PHD finger superfamily
    8. XM_047427944.1XP_047283900.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    9. XM_047427942.1XP_047283898.1  tripartite motif-containing protein 66 isoform X5

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A994J572
    10. XM_047427940.1XP_047283896.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    11. XM_011520504.1XP_011518806.1  tripartite motif-containing protein 66 isoform X1

      See identical proteins and their annotated locations for XP_011518806.1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
      UniProtKB/TrEMBL
      A0A8Z5E822
      Conserved Domains (5) summary
      cd05502
      Location:12181326
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd19794
      Location:208250
      Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cd19811
      Location:149185
      Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
      cl22851
      Location:11451193
      PHD_SF; PHD finger superfamily
    12. XM_011520516.1XP_011518818.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518818.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    13. XM_011520519.1XP_011518821.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518821.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    14. XM_011520513.1XP_011518815.1  tripartite motif-containing protein 66 isoform X7

      See identical proteins and their annotated locations for XP_011518815.1

      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:11321240
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:167292
      BBC; B-Box C-terminal domain
      cd00021
      Location:123158
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10591107
      PHD_SF; PHD finger superfamily
    15. XM_011520512.1XP_011518814.1  tripartite motif-containing protein 66 isoform X7

      See identical proteins and their annotated locations for XP_011518814.1

      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:11321240
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:167292
      BBC; B-Box C-terminal domain
      cd00021
      Location:123158
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10591107
      PHD_SF; PHD finger superfamily
    16. XM_047427945.1XP_047283901.1  tripartite motif-containing protein 66 isoform X8

      UniProtKB/TrEMBL
      A0A994J5L5
    17. XM_011520514.3XP_011518816.1  tripartite motif-containing protein 66 isoform X7

      See identical proteins and their annotated locations for XP_011518816.1

      UniProtKB/TrEMBL
      A0A994J5L5
      Conserved Domains (4) summary
      cd05502
      Location:11321240
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:167292
      BBC; B-Box C-terminal domain
      cd00021
      Location:123158
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10591107
      PHD_SF; PHD finger superfamily
    18. XM_047427946.1XP_047283902.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
    19. XM_011520515.1XP_011518817.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518817.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    20. XM_011520522.3XP_011518824.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518824.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Related
      ENSP00000516163.1, ENST00000705690.1
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    21. XM_006718398.4XP_006718461.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_006718461.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    22. XM_011520517.3XP_011518819.1  tripartite motif-containing protein 66 isoform X9

      See identical proteins and their annotated locations for XP_011518819.1

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    23. XM_017018631.1XP_016874120.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5, A0A994J7V7
      Conserved Domains (4) summary
      cd05502
      Location:10731181
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:108233
      BBC; B-Box C-terminal domain
      cd00021
      Location:6499
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl22851
      Location:10001048
      PHD_SF; PHD finger superfamily
    24. XM_047427947.1XP_047283903.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A994J5L5
    25. XM_011520527.2XP_011518829.1  tripartite motif-containing protein 66 isoform X15

      Conserved Domains (2) summary
      cd05502
      Location:569677
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      cd15625
      Location:496544
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
    26. XM_047427948.1XP_047283904.1  tripartite motif-containing protein 66 isoform X14

    27. XM_011520526.3XP_011518828.1  tripartite motif-containing protein 66 isoform X13

      Conserved Domains (2) summary
      cd05502
      Location:827935
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      cd15625
      Location:754802
      PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)
    28. XM_011520524.2XP_011518826.1  tripartite motif-containing protein 66 isoform X11

      Conserved Domains (2) summary
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd00021
      Location:209244
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    29. XM_011520525.2XP_011518827.1  tripartite motif-containing protein 66 isoform X12

      Conserved Domains (2) summary
      smart00502
      Location:253378
      BBC; B-Box C-terminal domain
      cd00021
      Location:209244
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

    RNA

    1. XR_930930.2 RNA Sequence

    2. XR_930929.2 RNA Sequence

    3. XR_930931.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      8693787..8764985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370650.1XP_054226625.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    2. XM_054370655.1XP_054226630.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    3. XM_054370649.1XP_054226624.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    4. XM_054370657.1XP_054226632.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    5. XM_054370653.1XP_054226628.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    6. XM_054370652.1XP_054226627.1  tripartite motif-containing protein 66 isoform X3

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    7. XM_054370651.1XP_054226626.1  tripartite motif-containing protein 66 isoform X2

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    8. XM_054370658.1XP_054226633.1  tripartite motif-containing protein 66 isoform X6

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    9. XM_054370656.1XP_054226631.1  tripartite motif-containing protein 66 isoform X5

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    10. XM_054370654.1XP_054226629.1  tripartite motif-containing protein 66 isoform X4

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    11. XM_054370648.1XP_054226623.1  tripartite motif-containing protein 66 isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8YEA1, O15016, Q9BQQ4
    12. XM_054370664.1XP_054226639.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    13. XM_054370667.1XP_054226642.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    14. XM_054370661.1XP_054226636.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L5
    15. XM_054370660.1XP_054226635.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L5
    16. XM_054370662.1XP_054226637.1  tripartite motif-containing protein 66 isoform X8

      UniProtKB/TrEMBL
      A0A994J5L5
    17. XM_054370659.1XP_054226634.1  tripartite motif-containing protein 66 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L5
    18. XM_054370668.1XP_054226643.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    19. XM_054370663.1XP_054226638.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    20. XM_054370670.1XP_054226645.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    21. XM_054370666.1XP_054226641.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    22. XM_054370665.1XP_054226640.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    23. XM_054370669.1XP_054226644.1  tripartite motif-containing protein 66 isoform X9

      UniProtKB/TrEMBL
      A0A994J5L5
    24. XM_054370671.1XP_054226646.1  tripartite motif-containing protein 66 isoform X10

      UniProtKB/TrEMBL
      A0A994J5L5
    25. XM_054370676.1XP_054226651.1  tripartite motif-containing protein 66 isoform X15

    26. XM_054370675.1XP_054226650.1  tripartite motif-containing protein 66 isoform X14

    27. XM_054370674.1XP_054226649.1  tripartite motif-containing protein 66 isoform X13

    28. XM_054370672.1XP_054226647.1  tripartite motif-containing protein 66 isoform X11

    29. XM_054370673.1XP_054226648.1  tripartite motif-containing protein 66 isoform X12

    RNA

    1. XR_008488499.1 RNA Sequence

    2. XR_008488498.1 RNA Sequence

    3. XR_008488500.1 RNA Sequence