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    Thap12 THAP domain containing 12 [ Mus musculus (house mouse) ]

    Gene ID: 72981, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Thap12provided by MGI
    Official Full Name
    THAP domain containing 12provided by MGI
    Primary source
    MGI:MGI:1920231
    See related
    Ensembl:ENSMUSG00000030753 AllianceGenome:MGI:1920231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dap4; Prkrir; Rpkrir; 2900052B10Rik
    Summary
    Predicted to enable DNA binding activity; metal ion binding activity; and protein dimerization activity. Located in nucleus. Is expressed in 1st branchial arch; 2nd branchial arch; heart; and trunk. Orthologous to human THAP12 (THAP domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.2), bladder adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thap12 in Genome Data Viewer
    Location:
    7 E1; 7 53.86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98352254..98367269)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98703036..98718062)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:105737605-105737906 Neighboring gene EMSY, BRCA2-interacting transcriptional repressor Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:105805164-105805273 Neighboring gene STARR-positive B cell enhancer mm9_chr7:105842676-105842977 Neighboring gene predicted gene 15506 Neighboring gene STARR-positive B cell enhancer ABC_E2833 Neighboring gene predicted gene, 57488 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene predicted gene, 33720

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Zhong X, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39047044,
    2. Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. Lin Y, et al. J Biol Chem, 2002 Dec 13. PMID 12384512
    3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Roussigne M, et al. Trends Biochem Sci, 2003 Feb. PMID 12575992
    4. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
    5. Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Prescott K, et al. Hum Genet, 2005 May. PMID 15778864

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
      Title: Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    52 kDa repressor of the inhibitor of the protein kinase
    Names
    58 kDa interferon-induced protein kinase-interacting protein
    P52rIPK
    THAP domain-containing protein 0
    THAP domain-containing protein 12
    interferon-inducible, double stranded RNA dependent inhibitor, protein-kinase
    p58IPK-interacting protein
    protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355114.1 → NP_001342043.1  52 kDa repressor of the inhibitor of the protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC111124
      Conserved Domains (2) summary
      pfam05699
      Location:498 → 555
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3 → 155
      DUF4371; Domain of unknown function (DUF4371)

    2. NM_028410.2 → NP_082686.1  52 kDa repressor of the inhibitor of the protein kinase isoform 1

      See identical proteins and their annotated locations for NP_082686.1

      Status: VALIDATED

      Source sequence(s)
      AC111124
      Consensus CDS
      CCDS21474.1
      UniProtKB/Swiss-Prot
      Q80Y58, Q9CUX1
      Related
      ENSMUSP00000033009.10, ENSMUST00000033009.16
      Conserved Domains (3) summary
      pfam05485
      Location:5 → 86
      THAP; THAP domain
      pfam05699
      Location:669 → 726
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:152 → 326
      DUF4371; Domain of unknown function (DUF4371)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      98352254..98367269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241915.4 → XP_011240217.1  52 kDa repressor of the inhibitor of the protein kinase isoform X1

      See identical proteins and their annotated locations for XP_011240217.1

      UniProtKB/Swiss-Prot
      Q80Y58, Q9CUX1
      Conserved Domains (3) summary
      pfam05485
      Location:5 → 86
      THAP; THAP domain
      pfam05699
      Location:669 → 726
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:152 → 326
      DUF4371; Domain of unknown function (DUF4371)

    2. XM_036153467.1 → XP_036009360.1  52 kDa repressor of the inhibitor of the protein kinase isoform X2

      Conserved Domains (2) summary
      pfam05699
      Location:498 → 555
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3 → 155
      DUF4371; Domain of unknown function (DUF4371)

    3. XM_006508224.5 → XP_006508287.1  52 kDa repressor of the inhibitor of the protein kinase isoform X2

      See identical proteins and their annotated locations for XP_006508287.1

      Conserved Domains (2) summary
      pfam05699
      Location:498 → 555
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
      pfam14291
      Location:3 → 155
      DUF4371; Domain of unknown function (DUF4371)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CUX1.2 GenPept UniProtKB/Swiss-Prot:Q9CUX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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