Mier1 MEIR1 treanscription regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mier1provided by MGI
Official Full Name: MEIR1 treanscription regulatorprovided by MGI
Primary source: MGI:MGI:1918398
See related: Ensembl:ENSMUSG00000028522 AllianceGenome:MGI:1918398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: er1; 4933425I22Rik; 5830411K19Rik
Summary: Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Orthologous to human MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 10.8), liver E14 (RPKM 8.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 47.36 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (102971521..103022951)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (103114324..103165754)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Title: Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases
Title: Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
This study represents the first immunohistochemical analysis of MI-ER1alpha expression in mammals.
Title: Protein expression of the transcriptional regulator MI-ER1 alpha in adult mouse tissues.
characterization of the mouse ortholog of mi-er1
Title: Cloning and characterization of the mouse ortholog of mi-er1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mier1 (e-PCR), detects polymorphism
- UniSTS:532318

D4Mit167 (e-PCR), detects polymorphism
- UniSTS:129946

NoName (e-PCR)
- UniSTS:234980

NoName (e-PCR)
- UniSTS:234981

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mesoderm induction early response protein 1

Names: early response 1; mesoderm induction early response 1 homolog (Xenopus laevis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039081.3 → NP_001034170.1 mesoderm induction early response protein 1 isoform b

See identical proteins and their annotated locations for NP_001034170.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 4. It encodes isoform b, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AL844176

Consensus CDS

CCDS38825.1

UniProtKB/Swiss-Prot

A1L3P9, B1AY29, B1AY34, Q5UAK0, Q5UAK1, Q5UAK2, Q5UAK3, Q6ZPL6, Q9D402

UniProtKB/TrEMBL

Q32P49

Related

ENSMUSP00000102470.2, ENSMUST00000106857.8

Conserved Domains (3) summary

smart00717
Location:287 → 332

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:287 → 331

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:181 → 230

ELM2; ELM2 domain
NM_001286221.1 → NP_001273150.1 mesoderm induction early response protein 1 isoform c

See identical proteins and their annotated locations for NP_001273150.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (c).

Source sequence(s)

AK136467, AL844176, AV322829, BC108273, CN538186

Consensus CDS

CCDS71432.1

UniProtKB/Swiss-Prot

Q5UAK0

UniProtKB/TrEMBL

Q32P49, Q8C929

Related

ENSMUSP00000095558.4, ENSMUST00000097945.10

Conserved Domains (3) summary

smart00717
Location:332 → 377

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:332 → 376

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:226 → 275

ELM2; ELM2 domain
NM_001286222.2 → NP_001273151.1 mesoderm induction early response protein 1 isoform a

See identical proteins and their annotated locations for NP_001273151.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 4. Variants 1 and 3 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AL844176

Consensus CDS

CCDS18408.1

UniProtKB/Swiss-Prot

Q5UAK0

UniProtKB/TrEMBL

Q32P49, Q8C929

Related

ENSMUSP00000102471.2, ENSMUST00000106858.8

Conserved Domains (2) summary

cd11661
Location:304 → 348

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:198 → 247

ELM2; ELM2 domain
NM_001286223.1 → NP_001273152.1 mesoderm induction early response protein 1 isoform d

See identical proteins and their annotated locations for NP_001273152.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 4. It encodes isoform d, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AK136467, AK168693, AV322829, BQ562973, CJ099524, CN701986

UniProtKB/Swiss-Prot

Q5UAK0

UniProtKB/TrEMBL

Q8C929

Conserved Domains (3) summary

smart00717
Location:286 → 331

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:286 → 330

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:180 → 229

ELM2; ELM2 domain
NM_001404080.1 → NP_001391009.1 mesoderm induction early response protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AL844176
NM_001404081.1 → NP_001391010.1 mesoderm induction early response protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AL844176
NM_001404082.1 → NP_001391011.1 mesoderm induction early response protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AL844176

Related

ENSMUSP00000030247.5, ENSMUST00000030247.11
NM_001404084.1 → NP_001391013.1 mesoderm induction early response protein 1 isoform d

Status: VALIDATED

Source sequence(s)

AL844176
NM_001404085.1 → NP_001391014.1 mesoderm induction early response protein 1 isoform e

Status: VALIDATED

Source sequence(s)

AL844176
NM_027696.4 → NP_081972.2 mesoderm induction early response protein 1 isoform a

See identical proteins and their annotated locations for NP_081972.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 4. Variants 1 and 3 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

AL844176

Consensus CDS

CCDS18408.1

UniProtKB/Swiss-Prot

Q5UAK0

UniProtKB/TrEMBL

Q32P49, Q8C929

Conserved Domains (2) summary

cd11661
Location:304 → 348

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:198 → 247

ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

102971521..103022951

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503399.3 → XP_006503462.1 mesoderm induction early response protein 1 isoform X2

Conserved Domains (2) summary

cd11661
Location:338 → 382

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:232 → 282

ELM2; ELM2 domain
XM_030253777.1 → XP_030109637.1 mesoderm induction early response protein 1 isoform X4

Conserved Domains (2) summary

cd11661
Location:260 → 304

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:154 → 204

ELM2; ELM2 domain
XM_030253779.1 → XP_030109639.1 mesoderm induction early response protein 1 isoform X5

Conserved Domains (2) summary

cd11661
Location:402 → 446

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:296 → 346

ELM2; ELM2 domain
XM_006503401.5 → XP_006503464.1 mesoderm induction early response protein 1 isoform X3

See identical proteins and their annotated locations for XP_006503464.1

UniProtKB/Swiss-Prot

Q5UAK0

Conserved Domains (2) summary

cd11661
Location:304 → 348

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:198 → 247

ELM2; ELM2 domain
XM_036164424.1 → XP_036020317.1 mesoderm induction early response protein 1 isoform X3

Conserved Domains (2) summary

cd11661
Location:304 → 348

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:198 → 247

ELM2; ELM2 domain
XM_036164426.1 → XP_036020319.1 mesoderm induction early response protein 1 isoform X3

Conserved Domains (2) summary

cd11661
Location:304 → 348

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

pfam01448
Location:198 → 247

ELM2; ELM2 domain