S1pr5 sphingosine-1-phosphate receptor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S1pr5provided by MGI
Official Full Name: sphingosine-1-phosphate receptor 5provided by MGI
Primary source: MGI:MGI:2150641
See related: Ensembl:ENSMUSG00000045087 AllianceGenome:MGI:2150641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edg8; S1P5; lpB4
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Is active in presynapse. Is expressed in several structures, including central nervous system; genital tubercle; liver; sensory organ; and unsegmented mesenchyme. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 10.8), stomach adult (RPKM 9.4) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.75 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21154213..21159739, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21242917..21248443, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Title: Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Beside representing a promising strategy to take into consideration for the development of alternative therapeutic options for Huntington's disease, selective stimulation of S1P receptor 5 may be also seen as an effective approach to target brain vasculature defects in the disease
Title: Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
reduced frequency of patrolling monocytes in bone marrow of KO mice
Title: S1PR5 is pivotal for the homeostasis of patrolling monocytes.
Coordinated changes in CXCR4 and S1P5 responsiveness govern NK-cell trafficking.
Title: Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
Fndings suggest that S1P(5) may mediate the effects of S1P in terms of regulating ERK-1/2 signaling in ES cells.
Title: Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.
These findings identify S1P5 as a T-bet-induced gene that is required for natural killer cell egress from lymph nodes and bone marrow.
Title: T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
Title: Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
The molecular identity, functional properties, and expression profile of the S1P5 (Edg-8) receptor have been characterized.
Title: Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.
Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.
Title: Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Edg8 (e-PCR), detects polymorphism
- UniSTS:474715

Edg8 (e-PCR), detects polymorphism
- UniSTS:496527

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 5

Names: S1P receptor 5; S1P receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; lysophospholipid receptor B4; sphingosine 1-phosphate receptor Edg-8; sphingosine-1-phosphate receptor LPB4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053190.2 → NP_444420.1 sphingosine 1-phosphate receptor 5

Status: VALIDATED

Source sequence(s)

AI848371, AI852113, AK081126, BY736639

Consensus CDS

CCDS22898.1

UniProtKB/Swiss-Prot

Q91X56, Q99MN8

Related

ENSMUSP00000113843.2, ENSMUST00000122088.2

Conserved Domains (1) summary

pfam00001
Location:53 → 307

7tm_1; 7 transmembrane receptor (rhodopsin family)