Zp3r zona pellucida 3 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zp3rprovided by MGI
Official Full Name: zona pellucida 3 receptorprovided by MGI
Primary source: MGI:MGI:104965
See related: Ensembl:ENSMUSG00000042554 AllianceGenome:MGI:104965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP56
Summary: Involved in binding activity of sperm to zona pellucida. Acts upstream of or within single fertilization. Located in acrosomal vesicle; cell body; and plasma membrane. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 24.4) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130474847..130557371, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130547110..130629634, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
Title: Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
These results provide further evidence that either ZP3R is not involved in sperm-zona pellucida binding or this process might be functionally redundant, involving multiple proteins for gamete interactions.
Title: Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization.
ZP3R monomer is processed from 67,000 M(r) to 43,000 M(r) by proteases coincident with release from the acrosome.
Title: Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix.
These results indicate that sperm ZP3R/sp56 is important for sperm-zona interactions during fertilization and support the concept that the acrosomal matrix plays an essential role in mediating the binding of sperm to the zona pellucida.
Title: Recombinant mouse sperm ZP3-binding protein (ZP3R/sp56) forms a high order oligomer that binds eggs and inhibits mouse fertilization in vitro.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within binding of sperm to zona pellucida	IDA Inferred from Direct Assay more info	PubMed
involved_in binding of sperm to zona pellucida	IDA Inferred from Direct Assay more info	PubMed
involved_in binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in response to symbiotic bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal lumen	IEA Inferred from Electronic Annotation more info
located_in acrosomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal matrix	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	EXP Inferred from Experiment more info	PubMed
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in outer acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of zona pellucida receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: zona pellucida sperm-binding protein 3 receptor

Names: sperm fertilization protein 56

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420657.1 → NP_001407586.1 zona pellucida sperm-binding protein 3 receptor isoform 1

Status: VALIDATED

Source sequence(s)

AC109283, AC122773

Related

ENSMUSP00000114401.2, ENSMUST00000128128.8
NM_009581.3 → NP_033607.2 zona pellucida sperm-binding protein 3 receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_033607.2

Status: VALIDATED

Source sequence(s)

AC109283, AC122773

Consensus CDS

CCDS15257.1

UniProtKB/Swiss-Prot

Q60736

UniProtKB/TrEMBL

G3X970, Q0VET1

Related

ENSMUSP00000045443.5, ENSMUST00000039862.11

Conserved Domains (4) summary

cd00033
Location:158 → 219

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:350 → 411

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:153 → 411

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:283 → 343

Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

130474847..130557371 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247992.3 → XP_011246294.1 zona pellucida sperm-binding protein 3 receptor isoform X2

Conserved Domains (3) summary

smart00032
Location:371 → 432

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:71 → 299

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:304 → 364

Sushi; Sushi repeat (SCR repeat)