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    Cntnap5a contactin associated protein-like 5A [ Mus musculus (house mouse) ]

    Gene ID: 636808, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cntnap5aprovided by MGI
    Official Full Name
    contactin associated protein-like 5Aprovided by MGI
    Primary source
    MGI:MGI:3643623
    See related
    Ensembl:ENSMUSG00000070695 AllianceGenome:MGI:3643623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Caspr5-1; EG636808
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell adhesion and proteolysis. Predicted to be located in membrane and neuron projection. Is expressed in central nervous system. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 2.7), cortex adult (RPKM 2.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cntnap5a in Genome Data Viewer
    Location:
    1 E2.3; 1 51.59 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (115612467..116515053)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (115684737..116587323)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01947 Neighboring gene leukotriene A4 hydrolase pseudogene Neighboring gene STARR-seq mESC enhancer starr_01948 Neighboring gene STARR-seq mESC enhancer starr_01949 Neighboring gene STARR-seq mESC enhancer starr_01950 Neighboring gene predicted gene, 50605 Neighboring gene tubulin, beta 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_01951 Neighboring gene STARR-seq mESC enhancer starr_01952 Neighboring gene STARR-seq mESC enhancer starr_01953 Neighboring gene STARR-seq mESC enhancer starr_01955 Neighboring gene STARR-seq mESC enhancer starr_01956 Neighboring gene STARR-seq mESC enhancer starr_01957 Neighboring gene STARR-seq mESC enhancer starr_01959 Neighboring gene STARR-seq mESC enhancer starr_01960 Neighboring gene STARR-seq mESC enhancer starr_01962 Neighboring gene STARR-seq mESC enhancer starr_01963 Neighboring gene predicted gene, 17777 Neighboring gene predicted gene, 24030

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Weichenhan D, et al. Mamm Genome, 2008 Oct-Dec. PMID 18949514
    2. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Traut W, et al. Mamm Genome, 2006 Jul. PMID 16845472
    3. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    contactin-associated protein like 5-1
    Names
    cell recognition molecule Caspr5-1
    cell recognition molecule Caspr5a
    contactin-associated protein-like 5a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077425.2 → NP_001070893.1  contactin-associated protein like 5-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070893.1

      Status: VALIDATED

      Source sequence(s)
      AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403
      Consensus CDS
      CCDS35689.1
      UniProtKB/Swiss-Prot
      Q0V8T9
      Related
      ENSMUSP00000035732.9, ENSMUST00000043725.9
      Conserved Domains (6) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00054
      Location:960 → 994
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:56 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:792 → 936
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:550 → 581
      EGF; EGF-like domain
      pfam02210
      Location:395 → 518
      Laminin_G_2; Laminin G domain

    2. NM_001371013.1 → NP_001357942.1  contactin-associated protein like 5-1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403
      Conserved Domains (6) summary
      smart00282
      Location:205 → 338
      LamG; Laminin G domain
      cd00054
      Location:961 → 995
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:56 → 173
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:793 → 937
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:551 → 582
      EGF; EGF-like domain
      pfam02210
      Location:396 → 519
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      115612467..116515053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529774.4 → XP_006529837.1  contactin-associated protein like 5-1 isoform X1

      Conserved Domains (6) summary
      smart00282
      Location:144 → 277
      LamG; Laminin G domain
      cd00054
      Location:900 → 934
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00057
      Location:2 → 112
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:732 → 876
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:490 → 521
      EGF; EGF-like domain
      pfam02210
      Location:335 → 458
      Laminin_G_2; Laminin G domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0V8T9.1 GenPept UniProtKB/Swiss-Prot:Q0V8T9

    Gene LinkOut

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