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    Hoxa7 homeobox A7 [ Mus musculus (house mouse) ]

    Gene ID: 15404, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hoxa7provided by MGI
    Official Full Name
    homeobox A7provided by MGI
    Primary source
    MGI:MGI:96179
    See related
    Ensembl:ENSMUSG00000038236 AllianceGenome:MGI:96179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M6; Hox-1.1
    Summary
    Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; regulation of transcription by RNA polymerase II; and stem cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and musculoskeletal system. Orthologous to human HOXA7 (homeobox A7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 14.9), kidney adult (RPKM 6.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hoxa7 in Genome Data Viewer
    Location:
    6 B3; 6 25.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52191471..52198757, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52215623..52218573, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene homeobox A3 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeobox A5 Neighboring gene homeobox A6 Neighboring gene mistral long non-coding RNA Neighboring gene predicted gene, 57855 Neighboring gene homeobox A9 Neighboring gene predicted gene, 52902 Neighboring gene microRNA 196b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells. Colberg-Poley AM, et al. Nature, 1985 Apr 25-May 1. PMID 2986010
    2. A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development. Knittel T, et al. Development, 1995 Apr. PMID 7538068
    3. Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Zimmer A, et al. Nature, 1989 Mar 9. PMID 2563901
    4. Retinoic acid response element in HOXA-7 regulatory region affects the rate, not the formation of anterior boundary expression. Kim MH, et al. Int J Dev Biol, 2002 May. PMID 12068955
    5. Position-specific activity of the Hox1.1 promoter in transgenic mice. Püschel AW, et al. Development, 1990 Mar. PMID 1971214

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the cohesin complex regulates PRC2 targeting to silence Hoxa7 and Hoxa9 and negatively regulate self-renewal. Our studies identify a novel epigenetic mechanism underlying leukemogenesis in AML patients with cohesin mutations.
      Title: The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.
    2. impact of Hoxa7 or Hoxa9 nullizygosity on hematopoietic progenitor compartments and their susceptibility to MLL-induced leukemias
      Title: Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
    3. The retinoic acid response element in the regulatory region affects the rate, not the formation of anterior boundary expression
      Title: Retinoic acid response element in HOXA-7 regulatory region affects the rate, not the formation of anterior boundary expression.
    4. during development, Hox expression boundaries become set along instructional cdx gradients, formed by cdx decay in cells moving away from the primitive streak region
      Title: Additional enhancer copies, with intact cdx binding sites, anteriorize Hoxa-7/lacZ expression in mouse embryos: evidence in keeping with an instructional cdx gradient.
    5. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1.
      Title: Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1.
    6. novel dna binding protein of Hoxa7 promoter; sequence analysis revealed that protein C171 contained one hydrophobic transmembrane domain in the N-terminal region and several putative phosphorylation and glycosylation sites
      Title: A novel factor associating with the upstream regulatory element of murine Hoxa-7 induces bacterial cell death.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein Hox-A7
    Names
    HOMEOBOX PROTEIN HOX-A7 (HOX-1.1) (M6-12) (M6)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419267.1 → NP_001406196.1  homeobox protein Hox-A7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/Swiss-Prot
      A2RS54, P02830, Q544P0

    2. NM_001419268.1 → NP_001406197.1  homeobox protein Hox-A7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/Swiss-Prot
      A2RS54, P02830, Q544P0

    3. NM_001419269.1 → NP_001406198.1  homeobox protein Hox-A7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/Swiss-Prot
      A2RS54, P02830, Q544P0

    4. NM_001419270.1 → NP_001406199.1  homeobox protein Hox-A7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC015583

    5. NM_001419271.1 → NP_001406200.1  homeobox protein Hox-A7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC015583

    6. NM_001419272.1 → NP_001406201.1  homeobox protein Hox-A7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      S4R2U5
      Related
      ENSMUSP00000138790.2, ENSMUST00000140316.2

    7. NM_001419273.1 → NP_001406202.1  homeobox protein Hox-A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      Q8JZW2

    8. NM_001419274.1 → NP_001406203.1  homeobox protein Hox-A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      Q8JZW2

    9. NM_001419276.1 → NP_001406205.1  homeobox protein Hox-A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      Q8JZW2

    10. NM_001419277.1 → NP_001406206.1  homeobox protein Hox-A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      Q8JZW2

    11. NM_001419278.1 → NP_001406207.1  homeobox protein Hox-A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      Q8JZW2

    12. NM_001419279.1 → NP_001406208.1  homeobox protein Hox-A7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC015583
      UniProtKB/TrEMBL
      Q8JZW2

    13. NM_010455.3 → NP_034585.1  homeobox protein Hox-A7 isoform 1

      See identical proteins and their annotated locations for NP_034585.1

      Status: VALIDATED

      Source sequence(s)
      AC015583
      Consensus CDS
      CCDS20145.1
      UniProtKB/Swiss-Prot
      A2RS54, P02830, Q544P0
      Related
      ENSMUSP00000048648.7, ENSMUST00000048715.9
      Conserved Domains (1) summary
      pfam00046
      Location:133 → 185
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52191471..52198757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02830.2 GenPept UniProtKB/Swiss-Prot:P02830

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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