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    Ankrd13c ankyrin repeat domain 13c [ Mus musculus (house mouse) ]

    Gene ID: 433667, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ankrd13cprovided by MGI
    Official Full Name
    ankyrin repeat domain 13cprovided by MGI
    Primary source
    MGI:MGI:2139746
    See related
    Ensembl:ENSMUSG00000039988 AllianceGenome:MGI:2139746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in protein retention in ER lumen; regulation of anoikis; and regulation of signaling receptor activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with endoplasmic reticulum. Is expressed in cranial ganglion; dorsal root ganglion; foregut; liver; and submandibular gland primordium. Orthologous to human ANKRD13C (ankyrin repeat domain 13C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.1), kidney adult (RPKM 16.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd13c in Genome Data Viewer
    Location:
    3 H4; 3 81.59 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157650886..157713671)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (157945420..158008034)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09381 Neighboring gene cystathionine gamma lyase Neighboring gene STARR-seq mESC enhancer starr_09383 Neighboring gene STARR-seq mESC enhancer starr_09384 Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene STARR-positive B cell enhancer ABC_E2102 Neighboring gene STARR-seq mESC enhancer starr_09387 Neighboring gene STARR-positive B cell enhancer ABC_E7952 Neighboring gene STARR-positive B cell enhancer ABC_E8807 Neighboring gene serine and arginine-rich splicing factor 11 Neighboring gene STARR-seq mESC enhancer starr_09389 Neighboring gene STARR-positive B cell enhancer ABC_E2684 Neighboring gene leucine rich repeat containing 40 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157723907-157724208

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ANKRD13C acts as a molecular chaperone for G protein-coupled receptors. Parent A, et al. J Biol Chem, 2010 Dec 24. PMID 20959461, Free PMC Article
    2. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein retention in ER lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 13C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013806.2 → NP_001013828.1  ankyrin repeat domain-containing protein 13C isoform 1

      See identical proteins and their annotated locations for NP_001013828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC117211, AC145301, AI835245, AK135906, BC065088, BQ562764, CF736962
      Consensus CDS
      CCDS17933.1
      UniProtKB/Swiss-Prot
      B2RST2, Q3UX43, Q6P1G4
      Related
      ENSMUSP00000038662.9, ENSMUST00000040787.13
      Conserved Domains (4) summary
      cd00204
      Location:115 → 199
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam11904
      Location:259 → 532
      GPCR_chapero_1; GPCR-chaperone
      pfam13637
      Location:144 → 197
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:115 → 141
      ANK; ANK repeat [structural motif]

    2. NM_001359909.1 → NP_001346838.1  ankyrin repeat domain-containing protein 13C isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5'UTR and initiates translation at a downstream start codon, compared to variant (1). The encoded isoform (2) has a shorter N-terminus, compared to isoform (1).
      Source sequence(s)
      AC117211, AC145301, AI835245
      Conserved Domains (1) summary
      pfam11904
      Location:1 → 263
      GPCR_chapero_1; GPCR-chaperone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      157650886..157713671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163152.1 → XP_036019045.1  ankyrin repeat domain-containing protein 13C isoform X2

      Conserved Domains (1) summary
      pfam11904
      Location:17 → 289
      GPCR_chapero_1; GPCR-chaperone

    2. XM_036163151.1 → XP_036019044.1  ankyrin repeat domain-containing protein 13C isoform X1

      Conserved Domains (3) summary
      sd00045
      Location:115 → 141
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:259 → 302
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:117 → 199
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_004941350.1 RNA Sequence

    2. XR_003954348.2 RNA Sequence

    3. XR_004941351.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UX43.2 GenPept UniProtKB/Swiss-Prot:Q3UX43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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