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    Cd177 CD177 antigen [ Mus musculus (house mouse) ]

    Gene ID: 68891, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cd177provided by MGI
    Official Full Name
    CD177 antigenprovided by MGI
    Primary source
    MGI:MGI:1916141
    See related
    Ensembl:ENSMUSG00000052212 AllianceGenome:MGI:1916141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdp3; 1190003K14Rik
    Summary
    Predicted to enable calcium-dependent protein binding activity; integrin binding activity; and protease binding activity. Predicted to be involved in several processes, including neutrophil extravasation; positive regulation of superoxide anion generation; and regulation of vesicle-mediated transport. Predicted to be located in plasma membrane and tertiary granule membrane. Predicted to be active in plasma membrane raft. Is expressed in bone marrow; liver; spleen; and thymus. Orthologous to human CD177 (CD177 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 70.2), liver E18 (RPKM 14.6) and 2 other tissues See more
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    Genomic context

    See Cd177 in Genome Data Viewer
    Location:
    7 A3; 7 12.58 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24443408..24459759, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24743983..24760334, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18276 Neighboring gene Ly6/PLAUR domain containing 10 Neighboring gene Ly6/PLAUR domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_18277 Neighboring gene CEA cell adhesion molecule 10 Neighboring gene STARR-seq mESC enhancer starr_18278 Neighboring gene predicted gene 5893

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell junction maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tertiary granule membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026862.4NP_081138.2  CD177 antigen precursor

      See identical proteins and their annotated locations for NP_081138.2

      Status: VALIDATED

      Source sequence(s)
      AC161488
      Consensus CDS
      CCDS20962.1
      UniProtKB/Swiss-Prot
      Q8R2S8
      Related
      ENSMUSP00000064934.6, ENSMUST00000063956.7
      Conserved Domains (2) summary
      pfam00021
      Location:511581
      UPAR_LY6; u-PAR/Ly-6 domain
      cl10471
      Location:705774
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24443408..24459759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250689.1XP_011248991.1  CD177 antigen isoform X3

      Conserved Domains (1) summary
      cl10471
      Location:137206
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    2. XM_017312278.1XP_017167767.1  CD177 antigen isoform X2

      Conserved Domains (1) summary
      cl10471
      Location:137206
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    3. XM_011250688.1XP_011248990.1  CD177 antigen isoform X1

      Conserved Domains (1) summary
      cl10471
      Location:137206
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...