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    Dlgap4 DLG associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 228836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlgap4provided by MGI
    Official Full Name
    DLG associated protein 4provided by MGI
    Primary source
    MGI:MGI:2138865
    See related
    Ensembl:ENSMUSG00000061689 AllianceGenome:MGI:2138865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DAP4; DAP-4; WBP16; Sapap4; SAPAP-4
    Summary
    This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 22.1), CNS E18 (RPKM 21.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dlgap4 in Genome Data Viewer
    Location:
    2 H1; 2 77.54 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156455431..156606283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156613633..156764363)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156373177-156373360 Neighboring gene AAR2 splicing factor homolog Neighboring gene predicted gene 14169 Neighboring gene predicted gene 14172 Neighboring gene predicted gene, 52566 Neighboring gene RIKEN cDNA 4930405A21 gene Neighboring gene STARR-seq mESC enhancer starr_06181 Neighboring gene STARR-seq mESC enhancer starr_06182 Neighboring gene myosin, light polypeptide 9, regulatory Neighboring gene ribosomal protein L9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice. Wang T, et al. Cereb Cortex, 2023 Feb 7. PMID 35368073
    2. Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. Schob C, et al. Transl Psychiatry, 2019 Jan 16. PMID 30664629, Free PMC Article
    3. SAPAP4 Deletion Causes Synaptic Dysfunction in the nucleus accumbens. Wu B, et al. Biochem Biophys Res Commun, 2018 Nov 10. PMID 30322620
    4. Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Wan Y, et al. Biol Psychiatry, 2014 Apr 15. PMID 23414593, Free PMC Article
    5. Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N mice. Pollak DD, et al. Behav Brain Res, 2005 Aug 30. PMID 15927279

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice.
      Title: Sapap4 deficiency leads to postsynaptic defects and abnormal behaviors relevant to hyperkinetic neuropsychiatric disorder in mice.
    2. Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development.
      Title: Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development.
    3. The behavioural alterations of SAPAP4-deficient mice are associated with dramatic changes in synapse morphology, function and plasticity, indicating that SAPAP4 is critical for the development of functional neuronal networks
      Title: Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice.
    4. The findings demonstrate that SAPAP4 plays a critical role in in the synaptic function of the nucleus accumbens.
      Title: SAPAP4 Deletion Causes Synaptic Dysfunction in the nucleus accumbens.
    5. Detection of significantly increased postsynaptic density-95 induced by behavioral training at the protein level per se is intriguing and supports the proposed importance of this molecule for neuronal information storage.
      Title: Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0964, MGC37636, MGC117830

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cholinergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disks large-associated protein 4
    Names
    PSD-95/SAP90-binding protein 4
    SAP90/PSD-95-associated protein 4
    WW domain-binding protein 16
    discs, large homolog-associated protein 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042487.1 → NP_001035952.1  disks large-associated protein 4 isoform b

      See identical proteins and their annotated locations for NP_001035952.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks several 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. It represents use of an alternate promoter. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      BC058948, BC085475, CF725232
      Consensus CDS
      CCDS38299.1
      UniProtKB/TrEMBL
      Q3UCF7
      Related
      ENSMUSP00000096749.6, ENSMUST00000099145.6
      Conserved Domains (1) summary
      pfam03359
      Location:121 → 453
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_001042488.2 → NP_001035953.1  disks large-associated protein 4 isoform c

      See identical proteins and their annotated locations for NP_001035953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks several 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. It represents use of an alternate promoter. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK150554, BC058948, BX004793, BY298512
      Consensus CDS
      CCDS38300.1
      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Related
      ENSMUSP00000105194.3, ENSMUST00000109566.9
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. NM_001277186.1 → NP_001264115.1  disks large-associated protein 4 isoform d

      See identical proteins and their annotated locations for NP_001264115.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon and contains an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      BC058948, BX004793, BX571766, BY122638, CJ111046, CJ117510, CX210973
      Consensus CDS
      CCDS71171.1
      UniProtKB/Swiss-Prot
      B1AZP2
      Related
      ENSMUSP00000105195.4, ENSMUST00000109567.10
      Conserved Domains (1) summary
      pfam03359
      Location:647 → 989
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. NM_001277187.1 → NP_001264116.1  disks large-associated protein 4 isoform e

      See identical proteins and their annotated locations for NP_001264116.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      BC058948, BX004793, BY122638, CJ111046, CJ117510, CX210973
      Consensus CDS
      CCDS71172.1
      UniProtKB/TrEMBL
      B7ZNS2
      Related
      ENSMUSP00000105196.4, ENSMUST00000109568.10
      Conserved Domains (1) summary
      pfam03359
      Location:643 → 975
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. NM_146128.6 → NP_666240.4  disks large-associated protein 4 isoform a

      See identical proteins and their annotated locations for NP_666240.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC058948, BX004793, BY122638, CJ111046, CJ117510, CX210973
      Consensus CDS
      CCDS16968.1
      UniProtKB/Swiss-Prot
      B1AZP2, B1AZP3, B7ZNS1, Q3KQQ8, Q6PD44, Q6XBF1, Q80TN3, Q8R3U9
      Related
      ENSMUSP00000126980.3, ENSMUST00000169464.9
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156455431..156606283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161542.1 → XP_036017435.1  disks large-associated protein 4 isoform X1

      UniProtKB/Swiss-Prot
      B1AZP2, B1AZP3, B7ZNS1, Q3KQQ8, Q6PD44, Q6XBF1, Q80TN3, Q8R3U9
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. XM_017317840.3 → XP_017173329.1  disks large-associated protein 4 isoform X4

      Conserved Domains (1) summary
      pfam03359
      Location:650 → 917
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. XM_006499341.4 → XP_006499404.1  disks large-associated protein 4 isoform X3

      Conserved Domains (1) summary
      pfam03359
      Location:660 → 920
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. XM_036161546.1 → XP_036017439.1  disks large-associated protein 4 isoform X2

      Conserved Domains (1) summary
      pfam03359
      Location:647 → 989
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. XM_006499340.5 → XP_006499403.1  disks large-associated protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006499403.1

      UniProtKB/Swiss-Prot
      B1AZP2, B1AZP3, B7ZNS1, Q3KQQ8, Q6PD44, Q6XBF1, Q80TN3, Q8R3U9
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. XM_030250649.1 → XP_030106509.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    7. XM_036161568.1 → XP_036017461.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    8. XM_006499350.5 → XP_006499413.1  disks large-associated protein 4 isoform X9

      See identical proteins and their annotated locations for XP_006499413.1

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    9. XM_030250650.2 → XP_030106510.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    10. XM_006499343.5 → XP_006499406.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499406.1

      UniProtKB/TrEMBL
      F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    11. XM_006499348.5 → XP_006499411.1  disks large-associated protein 4 isoform X9

      See identical proteins and their annotated locations for XP_006499411.1

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    12. XM_017317843.2 → XP_017173332.1  disks large-associated protein 4 isoform X7

      UniProtKB/TrEMBL
      Q3UCF7
      Conserved Domains (1) summary
      pfam03359
      Location:111 → 450
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    13. XM_017317848.2 → XP_017173337.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    14. XM_036161580.1 → XP_036017473.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    15. XM_036161581.1 → XP_036017474.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    16. XM_036161571.1 → XP_036017464.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    17. XM_006499346.5 → XP_006499409.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499409.1

      UniProtKB/TrEMBL
      F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    18. XM_030250653.2 → XP_030106513.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    19. XM_006499349.3 → XP_006499412.1  disks large-associated protein 4 isoform X9

      See identical proteins and their annotated locations for XP_006499412.1

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    20. XM_030250652.2 → XP_030106512.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    21. XM_006499344.4 → XP_006499407.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499407.1

      UniProtKB/TrEMBL
      F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    22. XM_030250651.2 → XP_030106511.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    23. XM_036161559.1 → XP_036017452.1  disks large-associated protein 4 isoform X8

      UniProtKB/TrEMBL
      F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    24. XM_036161553.1 → XP_036017446.1  disks large-associated protein 4 isoform X6

      UniProtKB/TrEMBL
      Q3UCF7
      Conserved Domains (1) summary
      pfam03359
      Location:149 → 491
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    25. XM_006499342.5 → XP_006499405.1  disks large-associated protein 4 isoform X5

      UniProtKB/TrEMBL
      Q3UCF7
      Conserved Domains (1) summary
      pfam03359
      Location:162 → 494
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    26. XM_006499345.5 → XP_006499408.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499408.1

      UniProtKB/TrEMBL
      F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:17 → 298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    27. XM_017317850.3 → XP_017173339.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    28. XM_036161569.1 → XP_036017462.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2, F6YMR0
      Conserved Domains (1) summary
      pfam03359
      Location:1 → 285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RNA

    1. XR_003952548.2 RNA Sequence

    2. XR_003952547.2 RNA Sequence

    3. XR_003952549.2 RNA Sequence

    4. XR_001782346.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AZP2.1 GenPept UniProtKB/Swiss-Prot:B1AZP2

    Gene LinkOut

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