Shank2 SH3 and multiple ankyrin repeat domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shank2provided by MGI
Official Full Name: SH3 and multiple ankyrin repeat domains 2provided by MGI
Primary source: MGI:MGI:2671987
See related: Ensembl:ENSMUSG00000037541 AllianceGenome:MGI:2671987
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ProSAP1; mKIAA1022
Summary: Enables ionotropic glutamate receptor binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and social behavior. Located in several cellular components, including dendritic spine; photoreceptor inner segment; and photoreceptor outer segment. Colocalizes with neurofilament and postsynaptic membrane. Is expressed in cerebellum; cerebral cortex; frontal cortex; neocortex; and neocortex region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 10.4), frontal lobe adult (RPKM 10.3) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.45 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (143531819..143979780)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (143978077..144426043)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autism patient-derived SHANK2B[Y29X] mutation affects the development of ALDH1A1 negative dopamine neuron.
Title: Autism patient-derived SHANK2B(Y29X) mutation affects the development of ALDH1A1 negative dopamine neuron.
Sex-specific modulation of safety learning in Shank2-deficient mice.
Title: Sex-specific modulation of safety learning in Shank2-deficient mice.
Increased social interaction in Shank2-deficient mice following acute social isolation.
Title: Increased social interaction in Shank2-deficient mice following acute social isolation.
Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.
Title: Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.
Enhanced fear limits behavioral flexibility in Shank2-deficient mice.
Title: Enhanced fear limits behavioral flexibility in Shank2-deficient mice.
S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.
Title: S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis.
Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
Title: Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
Title: Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice.
Title: Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice.
Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.
Title: Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit15 (e-PCR), detects polymorphism
- UniSTS:116753

RH138116 (e-PCR)
- UniSTS:220203

Shank2 (e-PCR), detects polymorphism
- UniSTS:496556

D7Mit47 (e-PCR), detects polymorphism
- UniSTS:131274

D7Mit177 (e-PCR), detects polymorphism
- UniSTS:131068

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
colocalizes_with neurofilament	IDA Inferred from Direct Assay more info	PubMed
located_in neurofilament	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: SH3 and multiple ankyrin repeat domains protein 2

Names: SH3/ankyrin domain gene 2; cortBP1; cortactin-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081370.3 → NP_001074839.3 SH3 and multiple ankyrin repeat domains protein 2 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate downstream promoter compared to variant 2 and encodes a shorter isoform (a) with a distinct N-terminus compared to isoform b.

Source sequence(s)

AC124520, AC140268

Consensus CDS

CCDS40201.1

UniProtKB/TrEMBL

A0A1C7ZMY3

Related

ENSMUSP00000146440.2, ENSMUST00000146006.3
NM_001113373.3 → NP_001106844.3 SH3 and multiple ankyrin repeat domains protein 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).

Source sequence(s)

AC124520, AC140268, AC152166

Consensus CDS

CCDS85484.1

UniProtKB/TrEMBL

A0A6I8MWY3

Related

ENSMUSP00000101520.3, ENSMUST00000105900.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

143531819..143979780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508521.5 → XP_006508584.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X1

Conserved Domains (7) summary

cd09506
Location:1845 → 1910

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1129 → 1538

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508520.5 → XP_006508583.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X1

Conserved Domains (7) summary

cd09506
Location:1845 → 1910

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1129 → 1538

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_030242323.2 → XP_030098183.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X11

Conserved Domains (7) summary

cd09506
Location:1788 → 1853

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:529 → 580

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 406

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1072 → 1481

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:625 → 717

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_030242322.2 → XP_030098182.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X11

Conserved Domains (7) summary

cd09506
Location:1788 → 1853

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:529 → 580

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 406

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1072 → 1481

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:625 → 717

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_017322092.3 → XP_017177581.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X10

Conserved Domains (6) summary

cd09506
Location:1827 → 1892

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_017322091.3 → XP_017177580.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X9

Conserved Domains (6) summary

cd09506
Location:1827 → 1892

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508525.5 → XP_006508588.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X4

Conserved Domains (7) summary

cd09506
Location:1838 → 1903

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1122 → 1531

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508526.5 → XP_006508589.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X5

Conserved Domains (7) summary

cd09506
Location:1836 → 1901

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1120 → 1529

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508529.5 → XP_006508592.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X8

Conserved Domains (7) summary

cd09506
Location:1829 → 1894

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1113 → 1522

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508519.5 → XP_006508582.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X1

Conserved Domains (7) summary

cd09506
Location:1845 → 1910

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1129 → 1538

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508524.5 → XP_006508587.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X3

Conserved Domains (7) summary

cd09506
Location:1838 → 1903

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1122 → 1531

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508523.4 → XP_006508586.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X2

Conserved Domains (7) summary

cd09506
Location:1841 → 1906

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1125 → 1534

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508527.4 → XP_006508590.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X6

Conserved Domains (7) summary

cd09506
Location:1834 → 1899

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1118 → 1527

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508522.5 → XP_006508585.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X1

Conserved Domains (7) summary

cd09506
Location:1845 → 1910

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1129 → 1538

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508528.5 → XP_006508591.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X7

Conserved Domains (7) summary

cd09506
Location:1831 → 1896

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:586 → 637

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 371

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1115 → 1524

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:682 → 774

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508530.5 → XP_006508593.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X11

Conserved Domains (7) summary

cd09506
Location:1788 → 1853

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:529 → 580

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 406

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1072 → 1481

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:625 → 717

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508531.5 → XP_006508594.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X12

Conserved Domains (7) summary

cd09506
Location:1784 → 1849

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:529 → 580

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 406

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1068 → 1477

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:625 → 717

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508532.5 → XP_006508595.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X13

UniProtKB/TrEMBL

D3Z5K8

Related

ENSMUSP00000101522.2, ENSMUST00000105902.8

Conserved Domains (7) summary

cd09506
Location:1774 → 1839

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:529 → 580

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03095
Location:164 → 406

PHA03095; ankyrin-like protein; Provisional

PHA03247
Location:1058 → 1467

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:625 → 717

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00045
Location:230 → 261

ANK; ANK repeat [structural motif]

cl28922
Location:55 → 142

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006508534.5 → XP_006508597.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X15

UniProtKB/TrEMBL

A0A6I8MWY3

Conserved Domains (4) summary

cd09506
Location:1406 → 1471

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:147 → 198

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03247
Location:690 → 1099

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:243 → 335

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006508533.3 → XP_006508596.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X14

UniProtKB/Swiss-Prot

E9QPH7, Q3UTK4, Q5DU07, Q80Z38

UniProtKB/TrEMBL

A0A6I8MWY3

Conserved Domains (4) summary

cd09506
Location:1409 → 1474

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:150 → 201

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03247
Location:693 → 1102

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:246 → 338

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030242325.2 → XP_030098185.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X16

UniProtKB/TrEMBL

A0A6I8MWY3

Conserved Domains (4) summary

cd09506
Location:1395 → 1460

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

cd11983
Location:150 → 201

SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2

PHA03247
Location:679 → 1088

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:246 → 338

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006508535.4 → XP_006508598.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X17

UniProtKB/TrEMBL

A0A6I8MWY3

Related

ENSMUSP00000159313.2, ENSMUST00000239495.2

Conserved Domains (3) summary

cd09506
Location:1218 → 1283

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:502 → 911

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:55 → 147

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036152869.1 → XP_036008762.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X22

Conserved Domains (2) summary

cd09506
Location:914 → 979

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:198 → 607

PHA03247; large tegument protein UL36; Provisional
XM_030242327.1 → XP_030098187.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X19

UniProtKB/TrEMBL

A0A1C7ZMY3

Conserved Domains (2) summary

cd09506
Location:1085 → 1150

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:369 → 778

PHA03247; large tegument protein UL36; Provisional
XM_030242326.1 → XP_030098186.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X18

UniProtKB/TrEMBL

A0A1C7ZMY3

Conserved Domains (3) summary

cd09506
Location:1178 → 1243

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:462 → 871

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:36 → 128

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006508536.4 → XP_006508599.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X19

UniProtKB/TrEMBL

A0A1C7ZMY3

Conserved Domains (2) summary

cd09506
Location:1085 → 1150

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:369 → 778

PHA03247; large tegument protein UL36; Provisional
XM_030242328.1 → XP_030098188.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X20

UniProtKB/TrEMBL

A0A1C7ZMY3

Conserved Domains (2) summary

cd09506
Location:961 → 1026

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:245 → 654

PHA03247; large tegument protein UL36; Provisional
XM_030242329.1 → XP_030098189.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X21

UniProtKB/TrEMBL

A0A1C7ZMY3

Conserved Domains (2) summary

cd09506
Location:954 → 1019

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:238 → 647

PHA03247; large tegument protein UL36; Provisional
XM_036152871.1 → XP_036008764.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X22

Conserved Domains (2) summary

cd09506
Location:914 → 979

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:198 → 607

PHA03247; large tegument protein UL36; Provisional
XM_036152870.1 → XP_036008763.1 SH3 and multiple ankyrin repeat domains protein 2 isoform X22

Conserved Domains (2) summary

cd09506
Location:914 → 979

SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins

PHA03247
Location:198 → 607

PHA03247; large tegument protein UL36; Provisional