Magea2 MAGE family member A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Magea2provided by MGI
Official Full Name: MAGE family member A2provided by MGI
Primary source: MGI:MGI:1333793
See related: Ensembl:ENSMUSG00000055746 AllianceGenome:MGI:1333793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mage-a2
Summary: Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; heart; liver; and reproductive system. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X F3; X 72.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (153810197..153816309, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (155027201..155033313, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:489222

G65194 (e-PCR)
- UniSTS:225864

Magea1 (e-PCR), detects polymorphism
- UniSTS:256622

AJ005526 (e-PCR)
- UniSTS:160903

NoName (e-PCR)
- UniSTS:491425

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanoma antigen family A, 2

Names: melanoma antigen, family A, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.