Xylt2 xylosyltransferase II [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xylt2provided by MGI
Official Full Name: xylosyltransferase IIprovided by MGI
Primary source: MGI:MGI:2444797
See related: Ensembl:ENSMUSG00000020868 AllianceGenome:MGI:2444797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XT2; XT-II; xylT-II; E030002B02Rik
Summary: Enables protein xylosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Acts upstream of or within heparin biosynthetic process and proteoglycan biosynthetic process. Predicted to be located in extracellular space. Predicted to be active in Golgi apparatus. Is expressed in alimentary system; cardiovascular system; integumental system; and nervous system. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in pseudoxanthoma elasticum. Orthologous to human XYLT2 (xylosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 16.2), thymus adult (RPKM 16.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 58.9 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94554671..94568341, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (94663845..94677518, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xylosyltransferase 2 deficiency and organ homeostasis.
Title: Xylosyltransferase 2 deficiency and organ homeostasis.
Using a xylosyltransferase II (Xylt2) deficient mouse model, studied the role of extracellular matrix sulfated glycosaminoglycans in adipose tissue and metabolic homeostasis.
Title: Adipose tissue loss and lipodystrophy in xylosyltransferase II deficient mice.
the data from Xylt2 knock-out mice and mice with liver neoplasia show that liver is a significant source of serum XylT2 activity.
Title: Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum.
alterations in proteoglycans (PGs)concentrations can occur due to loss of XylT2, and that reduced PGs can induce cyst development
Title: Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein xylosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein xylosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein xylosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein xylosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosaminoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heparin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: xylosyltransferase 2

Names: peptide O-xylosyltransferase 2

NP_665827.2

EC 2.4.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.