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    Derl3 Der1-like domain family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 70377, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Derl3provided by MGI
    Official Full Name
    Der1-like domain family, member 3provided by MGI
    Primary source
    MGI:MGI:1917627
    See related
    Ensembl:ENSMUSG00000009092 AllianceGenome:MGI:1917627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IZP6; derlin-3; 1810006I20Rik; 1810063P04Rik
    Summary
    Predicted to enable signal recognition particle binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein N-linked glycosylation via asparagine. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; genitourinary system; long bone epiphyseal plate; sensory organ; and spleen. Orthologous to human DERL3 (derlin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 82.9), genital fat pad adult (RPKM 42.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Derl3 in Genome Data Viewer
    Location:
    10 C1; 10 38.61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75729232..75731775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75893398..75895941)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40697 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor) Neighboring gene STARR-seq mESC enhancer starr_27162 Neighboring gene STARR-seq mESC enhancer starr_27164 Neighboring gene STARR-positive B cell enhancer ABC_E5149 Neighboring gene STARR-positive B cell enhancer ABC_E193 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit B1 Neighboring gene matrix metallopeptidase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel putative transmembrane protein, IZP6, is expressed in neural cells during embryogenesis. Tsukahara M, et al. Dev Growth Differ, 2001 Jun. PMID 11422294
    2. Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. Eura Y, et al. PLoS One, 2012. PMID 22479592, Free PMC Article
    3. Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart. Belmont PJ, et al. Circ Res, 2010 Feb 5. PMID 19940266, Free PMC Article
    4. Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress. Eura Y, et al. Int J Mol Sci, 2020 Aug 26. PMID 32858914, Free PMC Article
    5. Derlin-dependent accumulation of integral membrane proteins at cell surfaces. Schaheen B, et al. J Cell Sci, 2009 Jul 1. PMID 19509052

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.
      Title: Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.
    2. Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
      Title: Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.
    3. Study describes a potentially protective role for Derl3 in the heart.
      Title: Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118672, MGC144274, MGC144275

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal recognition particle binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signal recognition particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    derlin-3
    Names
    degradation in endoplasmic reticulum protein 3
    der1-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358983.1 → NP_001345912.1  derlin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB047555, AK007948, BC099615, BE952795
      Consensus CDS
      CCDS88024.1
      UniProtKB/TrEMBL
      A0A1W2P7B5
      Related
      ENSMUSP00000151623.2, ENSMUST00000217811.2
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 201
      DER1; Der1-like family

    2. NM_001358984.1 → NP_001345913.1  derlin-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB047555, AC142499, AK007348, AK007948, BC099615, BE952795
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 180
      DER1; Der1-like family

    3. NM_001358985.1 → NP_001345914.1  derlin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AB047555, AK007348, BE952795
      Conserved Domains (1) summary
      cl21536
      Location:13 → 161
      Rhomboid; Rhomboid family

    4. NM_024440.2 → NP_077760.1  derlin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC142499
      Consensus CDS
      CCDS23935.1
      UniProtKB/Swiss-Prot
      Q3T9L7, Q99KC6, Q9D8K3, Q9D954
      UniProtKB/TrEMBL
      Q14C34
      Related
      ENSMUSP00000009236.5, ENSMUST00000009236.6
      Conserved Domains (1) summary
      pfam04511
      Location:13 → 202
      DER1; Der1-like family

    RNA

    1. NR_152573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB047555, BC099615, BE952795

    2. NR_152574.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB047555, AK007348, BE952795
      Related
      ENSMUST00000218506.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75729232..75731775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8K3.1 GenPept UniProtKB/Swiss-Prot:Q9D8K3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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