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    Wnt5b wingless-type MMTV integration site family, member 5B [ Mus musculus (house mouse) ]

    Gene ID: 22419, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wnt5bprovided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 5Bprovided by MGI
    Primary source
    MGI:MGI:98959
    See related
    Ensembl:ENSMUSG00000030170 AllianceGenome:MGI:98959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wnt-5b
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.7), limb E14.5 (RPKM 3.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wnt5b in Genome Data Viewer
    Location:
    6 F1; 6 56.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119409493..119521847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119432531..119544824, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119286263-119286553 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene STARR-positive B cell enhancer ABC_E9099 Neighboring gene adiponectin receptor 2 Neighboring gene STARR-seq mESC enhancer starr_17147 Neighboring gene STARR-seq mESC enhancer starr_17149 Neighboring gene predicted gene, 40397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119472087-119472240 Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene predicted gene, 30690 Neighboring gene predicted gene, 52875 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene STARR-seq mESC enhancer starr_17152 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene STARR-seq mESC enhancer starr_17154 Neighboring gene family with sequence similarity 76, member A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway. Bradley EW, et al. J Cell Physiol, 2011 Jun. PMID 21413026
    2. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation. Wu M, et al. Pain, 2020 Mar. PMID 31738230, Free PMC Article
    3. Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors. Wu X, et al. Cells, 2019 Sep 25. PMID 31557955, Free PMC Article
    4. Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis. Luan Y, et al. Cell Rep, 2024 Mar 26. PMID 38461416, Free PMC Article
    5. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Kanazawa A, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796911

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.
      Title: Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.
    2. Results found that WNT-5B expression level is enhanced in ageing mice. WNT-5B repress the growth of lung organoid co-cultures of fibroblasts and epithelial progenitors, and preferentially restraining both the growth and differentiation of the alveolar epithelial progenitors. These results provide evidence that WNT-5B, along with WNT-5A negatively regulate the canonical WNT signaling pathway in alveolar epithelium.
      Title: Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors.
    3. opposing gradients of Wnt5a and Wnt5b and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
      Title: A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
    4. Wnt5b activated known calcium-dependent signaling pathways and JNK, a component of the planar cell polarity pathway.
      Title: Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway.
    5. this study aimed at defining the expression profile and function of Wnt5a and Wnt5b during adipogenesis by determining their effect on aP2 and PPARgamma expression and assessing the level of beta-catenin translocation in mouse 3T3-L1 preadipocytes.
      Title: Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a.
    6. hCG was found to up-regulate these wnt ligands in mouse mammary gland, independent of the changes in ovarian steroidogenesis
      Title: Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation.
    7. Wnt5b may promote adipogenesis in 3T3-L1 cells, at least in part, by antagonizing the canonical Wnt/beta-catenin pathway
      Title: Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes.
    8. Secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.
      Title: Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.
    9. Data indicate that Wnt5a and Wnt5b control the pace of transitions between different chondrocyte zones.
      Title: Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of convergent extension involved in gastrulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein Wnt-5b
    Names
    wingless-related MMTV integration site 5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271757.2 → NP_001258686.1  protein Wnt-5b precursor

      See identical proteins and their annotated locations for NP_001258686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC126607
      Consensus CDS
      CCDS20474.2
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
      Related
      ENSMUSP00000113188.2, ENSMUST00000117171.8
      Conserved Domains (1) summary
      pfam00110
      Location:54 → 359
      wnt; wnt family

    2. NM_001271758.2 → NP_001258687.1  protein Wnt-5b precursor

      See identical proteins and their annotated locations for NP_001258687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC126607
      Consensus CDS
      CCDS20474.2
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
      Related
      ENSMUSP00000112819.2, ENSMUST00000118120.8
      Conserved Domains (1) summary
      pfam00110
      Location:54 → 359
      wnt; wnt family

    3. NM_001410505.1 → NP_001397434.1  protein Wnt-5b precursor

      Status: VALIDATED

      Source sequence(s)
      AC126607, AC128662
      UniProtKB/Swiss-Prot
      P22726, Q91XF5

    4. NM_009525.4 → NP_033551.2  protein Wnt-5b precursor

      See identical proteins and their annotated locations for NP_033551.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC126607, AC128662
      Consensus CDS
      CCDS20474.2
      UniProtKB/Swiss-Prot
      P22726, Q91XF5
      UniProtKB/TrEMBL
      D3YTW9
      Related
      ENSMUSP00000137065.2, ENSMUST00000178696.8
      Conserved Domains (1) summary
      pfam00110
      Location:54 → 359
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119409493..119521847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166025.1 → XP_036021918.1  protein Wnt-5b isoform X1

      UniProtKB/TrEMBL
      D3YTW9
      Conserved Domains (1) summary
      cd19348
      Location:83 → 394
      Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins

    2. XM_036166026.1 → XP_036021919.1  protein Wnt-5b isoform X2

      UniProtKB/TrEMBL
      A0A0R4J1M1, D3YTW9
      Conserved Domains (1) summary
      cd19348
      Location:61 → 372
      Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22726.2 GenPept UniProtKB/Swiss-Prot:P22726

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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