Reck reversion-inducing-cysteine-rich protein with kazal motifs [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reckprovided by MGI
Official Full Name: reversion-inducing-cysteine-rich protein with kazal motifsprovided by MGI
Primary source: MGI:MGI:1855698
See related: Ensembl:ENSMUSG00000028476 AllianceGenome:MGI:1855698
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: St15; mRECK
Summary: Enables Wnt-protein binding activity; coreceptor activity; and endopeptidase inhibitor activity. Involved in several processes, including negative regulation of metalloendopeptidase activity; positive regulation of canonical Wnt signaling pathway; and regulation of establishment of blood-brain barrier. Acts upstream of or within several processes, including blood vessel maturation; embryo implantation; and embryonic forelimb morphogenesis. Located in plasma membrane. Part of Wnt signalosome. Is expressed in several structures, including Meckel's cartilage; diaphragm; genitourinary system; and musculoskeletal system. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 23.2), lung adult (RPKM 18.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 23.05 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43875521..43944806)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43875521..43944806)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.
Title: Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
Title: The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck.
Title: MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck.
Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
Title: Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.
Impact of Reck expression and promoter activity in neuronal in vitro differentiation.
Title: Impact of Reck expression and promoter activity in neuronal in vitro differentiation.
Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice.
Title: Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice.
Structure of the RECK CC domain, an evolutionary anomaly.
Title: Structure of the RECK CC domain, an evolutionary anomaly.
Mouse embryos carrying Reck(P256A,W261A) have severe defects in forebrain angiogenesis, providing the strongest evidence to date that Reck promotes central nervous system angiogenesis by specifically stimulating Wnt7a and Wnt7b signaling.
Title: Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.
Reck was identified to be one of the target genes of miR-497-5p, and Reck could suppress the expression of matrix metalloproteinase-2 (Mmp2) and Mmp9, which could activate latent transforming growth factor-beta1 (TGF-beta1).
Title: The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis.
experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB.
Title: Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel maturation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryo implantation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: reversion-inducing cysteine-rich protein with Kazal motifs

Names: Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK); membrane-anchored glycoprotein RECK; suppression of tumorigenicity 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016678.3 → NP_057887.2 reversion-inducing cysteine-rich protein with Kazal motifs precursor

See identical proteins and their annotated locations for NP_057887.2

Status: VALIDATED

Source sequence(s)

AL772204, AL773539

Consensus CDS

CCDS18116.1

UniProtKB/Swiss-Prot

B1AWM3, Q9Z0J1

UniProtKB/TrEMBL

A2RSP9

Related

ENSMUSP00000030198.7, ENSMUST00000030198.7

Conserved Domains (1) summary

pfam14828
Location:802 → 867

Amnionless; Amnionless

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

43875521..43944806

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253674.2 → XP_030109534.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

UniProtKB/TrEMBL

A2RSP9

Conserved Domains (1) summary

cl28910
Location:489 → 571

MFS; Major Facilitator Superfamily