Magea1 MAGE family member A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Magea1provided by MGI
Official Full Name: MAGE family member A1provided by MGI
Primary source: MGI:MGI:1333834
See related: Ensembl:ENSMUSG00000096644 AllianceGenome:MGI:1333834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mage-a1
Summary: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: X F3; X 72.38 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (153871515..153872786, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (155088519..155089790, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP70MAGEA1 delivered via microbubbles clearly inhibited and delayed the growth of MAGEA1expressing B16 melanomas in mice and improved the survival times of these animals compared with the fusion protein alone.
Title: Gas‑filled ultrasound microbubbles enhance the immunoactivity of the HSP70‑MAGEA1 fusion protein against MAGEA1‑expressing tumours.
results indicate that the fusion of Hsp70 to Mage-a1 can enhance immune responses and anti-tumor effects against Mage-a1-expressing tumors
Title: Fusion of Hsp70 to Mage-a1 enhances the potency of vaccine-specific immune responses.

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General gene information

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Markers

G65194 (e-PCR)
- UniSTS:225864

Magea1 (e-PCR), detects polymorphism
- UniSTS:256622

AJ005526 (e-PCR)
- UniSTS:160903

NoName (e-PCR)
- UniSTS:491425

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanoma antigen family A, 1

Names: melanoma antigen, family A, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.