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    Neil2 nei like 2 (E. coli) [ Mus musculus (house mouse) ]

    Gene ID: 382913, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Neil2provided by MGI
    Official Full Name
    nei like 2 (E. coli)provided by MGI
    Primary source
    MGI:MGI:2686058
    See related
    Ensembl:ENSMUSG00000035121 AllianceGenome:MGI:2686058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEH2; Gm1212
    Summary
    Enables microtubule binding activity. Predicted to be involved in base-excision repair. Located in cytoplasm and mitotic spindle. Is expressed in primordial germ cell of gonad. Orthologous to human NEIL2 (nei like DNA glycosylase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Neil2 in Genome Data Viewer
    Location:
    14 D1; 14 33.24 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63419888..63431604, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63182439..63194154, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene microRNA 12185 Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene STARR-seq mESC enhancer starr_36919 Neighboring gene STARR-positive B cell enhancer ABC_E3119 Neighboring gene predicted gene, 53861 Neighboring gene GATA binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_36921 Neighboring gene predicted gene 4151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease. Scheffler K, et al. Free Radic Biol Med, 2020 May 20. PMID 32259578
    2. Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2. Hailer MK, et al. DNA Repair (Amst), 2005 Jan 2. PMID 15533836
    3. Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection. Pan L, et al. J Biol Chem, 2023 Aug. PMID 37423306, Free PMC Article
    4. NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Hildrestrand GA, et al. Commun Biol, 2021 Dec 2. PMID 34857879, Free PMC Article
    5. Intrapulmonary administration of purified NEIL2 abrogates NF-κB-mediated inflammation. Tapryal N, et al. J Biol Chem, 2021 Jan-Jun. PMID 33932404, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nei-like DNA glycosylase 2 selectively antagonizes interferon-beta expression upon respiratory syncytial virus infection.
      Title: Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection.
    2. NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
      Title: NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
    3. Intrapulmonary administration of purified NEIL2 abrogates NF-kappaB-mediated inflammation.
      Title: Intrapulmonary administration of purified NEIL2 abrogates NF-κB-mediated inflammation.
    4. DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
      Title: DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
    5. The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells.
      Title: The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells.
    6. Thus, NEIL1 and NEIL2 DNA glycosylases protect mitochondrial DNA against oxidative damage during neural crest differentiation.
      Title: NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress.
    7. NEIL2 plays an important role in long term genomic maintenance
      Title: Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
    8. the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity.
      Title: Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding.
    9. NEIL1 and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals.
      Title: Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.
    10. Keap1 recruits NEH2 through binding to ETGE and DLG motifs.
      Title: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease 8-like 2
    Names
    DNA glycosylase/AP lyase Neil2
    DNA-(apurinic or apyrimidinic site) lyase Neil2
    endonuclease VIII-like 2
    nei homolog 2
    nei-like protein 2
    NP_963904.2
    XP_006519262.1
    XP_006519264.1
    XP_006519266.1
    XP_011243410.1
    XP_011243411.1
    XP_036014637.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201610.2 → NP_963904.2  endonuclease 8-like 2

      See identical proteins and their annotated locations for NP_963904.2

      Status: VALIDATED

      Source sequence(s)
      AC090654, BC115709
      Consensus CDS
      CCDS36949.1
      UniProtKB/Swiss-Prot
      G3X969, Q6R2P8
      UniProtKB/TrEMBL
      Q1RLK4
      Related
      ENSMUSP00000045200.5, ENSMUST00000038229.5
      Conserved Domains (3) summary
      cd08968
      Location:1 → 181
      MeNeil2_N; N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2)
      COG0266
      Location:151 → 316
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      pfam11650
      Location:46 → 122
      P22_Tail-4; P22 tail accessory factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      63419888..63431604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245109.4 → XP_011243411.1  endonuclease 8-like 2 isoform X2

      See identical proteins and their annotated locations for XP_011243411.1

      Conserved Domains (2) summary
      COG0266
      Location:121 → 286
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      cl03119
      Location:4 → 151
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    2. XM_006519199.5 → XP_006519262.1  endonuclease 8-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006519262.1

      UniProtKB/Swiss-Prot
      G3X969, Q6R2P8
      UniProtKB/TrEMBL
      Q1RLK4
      Conserved Domains (3) summary
      cd08968
      Location:1 → 181
      MeNeil2_N; N-terminal domain of metazoan Nei-like glycosylase 2 (NEIL2)
      COG0266
      Location:151 → 316
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      pfam11650
      Location:46 → 122
      P22_Tail-4; P22 tail accessory factor

    3. XM_011245108.4 → XP_011243410.1  endonuclease 8-like 2 isoform X2

      See identical proteins and their annotated locations for XP_011243410.1

      Conserved Domains (2) summary
      COG0266
      Location:121 → 286
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      cl03119
      Location:4 → 151
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    4. XM_006519201.5 → XP_006519264.1  endonuclease 8-like 2 isoform X3

      UniProtKB/TrEMBL
      Q1RLK4
      Conserved Domains (2) summary
      COG0266
      Location:110 → 275
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      cl03119
      Location:5 → 140
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    5. XM_036158744.1 → XP_036014637.1  endonuclease 8-like 2 isoform X4

      Conserved Domains (2) summary
      COG0266
      Location:90 → 255
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
      cl03119
      Location:58 → 120
      FpgNei_N; N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases

    6. XM_006519203.4 → XP_006519266.1  endonuclease 8-like 2 isoform X5

      Conserved Domains (1) summary
      COG0266
      Location:3 → 159
      Nei; Formamidopyrimidine-DNA glycosylase [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6R2P8.4 GenPept UniProtKB/Swiss-Prot:Q6R2P8

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