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    Tmem175 transmembrane protein 175 [ Mus musculus (house mouse) ]

    Gene ID: 72392, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem175provided by MGI
    Official Full Name
    transmembrane protein 175provided by MGI
    Primary source
    MGI:MGI:1919642
    See related
    Ensembl:ENSMUSG00000013495 AllianceGenome:MGI:1919642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mTMEM175; 3010001K23Rik
    Summary
    Enables potassium ion leak channel activity. Involved in lysosome organization; neuron cellular homeostasis; and potassium ion transmembrane transport. Predicted to be located in endosome membrane and lysosomal membrane. Predicted to be active in endosome and lysosome. Orthologous to human TMEM175 (transmembrane protein 175). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 32.5), ovary adult (RPKM 20.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem175 in Genome Data Viewer
    Location:
    5 F; 5 53.24 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108777649..108795636)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108629779..108647770)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13909 Neighboring gene complexin 1 Neighboring gene cyclin G associated kinase Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1 Neighboring gene predicted gene, 42151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systemic knockout of Tmem175 results in aberrant differentiation but no effect on hematopoietic reconstitution. Su J, et al. Stem Cell Res, 2024 Sep. PMID 38878670
    2. Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease. Qu L, et al. EMBO Rep, 2022 Sep 5. PMID 35913019, Free PMC Article
    3. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds. Pergel E, et al. Int J Mol Sci, 2021 Sep 29. PMID 34638858, Free PMC Article
    4. Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease. Feng T, et al. Ageing Res Rev, 2024 Sep. PMID 38960046
    5. Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. Hu M, et al. Cell, 2022 Jun 23. PMID 35750034, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease.
      Title: Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease.
    2. Systemic knockout of Tmem175 results in aberrant differentiation but no effect on hematopoietic reconstitution.
      Title: Systemic knockout of Tmem175 results in aberrant differentiation but no effect on hematopoietic reconstitution.
    3. Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
      Title: Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
    4. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
      Title: Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
    5. TMEM175 comprises a potassium (K) channel that underlies the molecular mechanism of lysosomal K(+) permeability.
      Title: TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion leak channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables potassium ion leak channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysosomal lumen pH elevation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosomal lumen pH elevation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of lysosomal lumen pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lysosomal lumen pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    endosomal/lysosomal proton channel TMEM175
    Names
    endosomal/lysomomal potassium channel TMEM175
    endosomal/lysosomal potassium channel TMEM175
    potassium channel TMEM175

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163531.1 → NP_001157003.1  endosomal/lysosomal proton channel TMEM175 isoform 2

      See identical proteins and their annotated locations for NP_001157003.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK034579, BB653267
      UniProtKB/TrEMBL
      Q8BM80
      Conserved Domains (1) summary
      pfam06736
      Location:256 → 352
      DUF1211; Protein of unknown function (DUF1211)

    2. NM_001163532.1 → NP_001157004.1  endosomal/lysosomal proton channel TMEM175 isoform 1

      See identical proteins and their annotated locations for NP_001157004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AI526594, AK013879, AK034579, BB653267
      Consensus CDS
      CCDS19514.1
      UniProtKB/Swiss-Prot
      Q3TDC4, Q99K00, Q9CXY1
      Related
      ENSMUSP00000068607.7, ENSMUST00000063272.13
      Conserved Domains (1) summary
      pfam06736
      Location:257 → 353
      DUF1211; Protein of unknown function (DUF1211)

    3. NM_001359423.1 → NP_001346352.1  endosomal/lysosomal proton channel TMEM175 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC161813
      Consensus CDS
      CCDS19514.1
      UniProtKB/Swiss-Prot
      Q3TDC4, Q99K00, Q9CXY1
      Related
      ENSMUSP00000112780.2, ENSMUST00000120327.3
      Conserved Domains (1) summary
      pfam06736
      Location:257 → 353
      DUF1211; Protein of unknown function (DUF1211)

    4. NM_001359426.1 → NP_001346355.1  endosomal/lysosomal proton channel TMEM175 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161813
      Conserved Domains (1) summary
      pfam06736
      Location:178 → 274
      DUF1211; Protein of unknown function (DUF1211)

    5. NM_001359427.1 → NP_001346356.1  endosomal/lysosomal proton channel TMEM175 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161813, BU057278
      Conserved Domains (1) summary
      pfam06736
      Location:144 → 240
      DUF1211; Protein of unknown function (DUF1211)

    6. NM_028223.3 → NP_082499.3  endosomal/lysosomal proton channel TMEM175 isoform 1

      See identical proteins and their annotated locations for NP_082499.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AK013879, AK034579, BB653267, BY323049, DN175171
      Consensus CDS
      CCDS19514.1
      UniProtKB/Swiss-Prot
      Q3TDC4, Q99K00, Q9CXY1
      Related
      ENSMUSP00000077437.7, ENSMUST00000078323.13
      Conserved Domains (1) summary
      pfam06736
      Location:257 → 353
      DUF1211; Protein of unknown function (DUF1211)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108777649..108795636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535230.5 → XP_006535293.1  endosomal/lysosomal proton channel TMEM175 isoform X1

      See identical proteins and their annotated locations for XP_006535293.1

      UniProtKB/Swiss-Prot
      Q3TDC4, Q99K00, Q9CXY1
      Conserved Domains (1) summary
      pfam06736
      Location:257 → 353
      DUF1211; Protein of unknown function (DUF1211)

    2. XM_006535232.4 → XP_006535295.1  endosomal/lysosomal proton channel TMEM175 isoform X2

      See identical proteins and their annotated locations for XP_006535295.1

      Conserved Domains (1) summary
      pfam06736
      Location:229 → 325
      DUF1211; Protein of unknown function (DUF1211)

    3. XM_036165524.1 → XP_036021417.1  endosomal/lysosomal proton channel TMEM175 isoform X3

      Conserved Domains (1) summary
      pfam06736
      Location:144 → 240
      DUF1211; Protein of unknown function (DUF1211)

    4. XM_036165526.1 → XP_036021419.1  endosomal/lysosomal proton channel TMEM175 isoform X4

      Conserved Domains (1) summary
      pfam06736
      Location:116 → 212
      DUF1211; Protein of unknown function (DUF1211)

    5. XM_006535233.4 → XP_006535296.1  endosomal/lysosomal proton channel TMEM175 isoform X2

      See identical proteins and their annotated locations for XP_006535296.1

      Conserved Domains (1) summary
      pfam06736
      Location:229 → 325
      DUF1211; Protein of unknown function (DUF1211)

    6. XM_030254826.2 → XP_030110686.1  endosomal/lysosomal proton channel TMEM175 isoform X3

      Conserved Domains (1) summary
      pfam06736
      Location:144 → 240
      DUF1211; Protein of unknown function (DUF1211)

    7. XM_030254827.2 → XP_030110687.1  endosomal/lysosomal proton channel TMEM175 isoform X4

      Conserved Domains (1) summary
      pfam06736
      Location:116 → 212
      DUF1211; Protein of unknown function (DUF1211)

    8. XM_036165523.1 → XP_036021416.1  endosomal/lysosomal proton channel TMEM175 isoform X1

      UniProtKB/Swiss-Prot
      Q3TDC4, Q99K00, Q9CXY1
      Conserved Domains (1) summary
      pfam06736
      Location:257 → 353
      DUF1211; Protein of unknown function (DUF1211)

    9. XM_006535237.4 → XP_006535300.1  endosomal/lysosomal proton channel TMEM175 isoform X6

      UniProtKB/TrEMBL
      Q8BHJ8
      Conserved Domains (1) summary
      pfam06736
      Location:32 → 121
      DUF1211; Protein of unknown function (DUF1211)

    10. XM_006535236.3 → XP_006535299.1  endosomal/lysosomal proton channel TMEM175 isoform X5

      Conserved Domains (1) summary
      pfam06736
      Location:16 → 112
      DUF1211; Protein of unknown function (DUF1211)

    RNA

    1. XR_004942569.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXY1.2 GenPept UniProtKB/Swiss-Prot:Q9CXY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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