Cd300ld3 CD300 molecule like family member D3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300ld3provided by MGI
Official Full Name: CD300 molecule like family member D3provided by MGI
Primary source: MGI:MGI:2687214
See related: Ensembl:ENSMUSG00000069607 AllianceGenome:MGI:2687214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clm3; Lmir7; clm-3; Cd300lh
Summary: Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within positive regulation of protein ubiquitination and positive regulation of toll-like receptor 9 signaling pathway. Located in endosome and lysosome. Orthologous to human CD300LD (CD300 molecule like family member d). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 48.4), subcutaneous fat pad adult (RPKM 26.4) and 11 other tissues See more
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Genomic context

Location:: 11 E2; 11 80.58 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114932930..114939244, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115042104..115048419, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transgenic CLM-3 selectively promotes production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in macrophages triggered by toll-like receptor (TLR)9, but not TLR4 or TLR3.
Title: CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination.
Data show that LMIR7/CLM-3 shares similarities with LMIR4/CLM-5, although they are differentially regulated in their distribution, expression, and function.
Title: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in immune response-activating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of toll-like receptor 9 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of toll-like receptor 9 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CMRF35-like molecule 3

Names: CD300 antigen like family member H; CMRF-35-like molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199201.2 → NP_954671.1 CMRF35-like molecule 3 precursor

See identical proteins and their annotated locations for NP_954671.1

Status: VALIDATED

Source sequence(s)

AL607025, AY457049

Consensus CDS

CCDS25617.1

UniProtKB/Swiss-Prot

Q6SJQ5

UniProtKB/TrEMBL

A2A7W0

Related

ENSMUSP00000090116.4, ENSMUST00000092459.4

Conserved Domains (2) summary

cd05716
Location:27 → 124

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:25 → 125

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

114932930..114939244 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533653.4 → XP_006533716.1 CMRF35-like molecule 3 isoform X1

Conserved Domains (1) summary

cd05716
Location:27 → 124

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains