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    Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta [ Mus musculus (house mouse) ]

    Gene ID: 66326, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnajc5bprovided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C5 betaprovided by MGI
    Primary source
    MGI:MGI:1913576
    See related
    Ensembl:ENSMUSG00000027606 AllianceGenome:MGI:1913576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700008A05Rik
    Summary
    Predicted to be located in membrane. Is expressed in inner ear vestibular component. Orthologous to human DNAJC5B (DnaJ heat shock protein family (Hsp40) member C5 beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 67.1) See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc5b in Genome Data Viewer
    Location:
    3 A2; 3 5.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19562755..19665026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19508591..19610862)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:19250042-19250343 Neighboring gene predicted gene, 52602 Neighboring gene predicted gene, 42188 Neighboring gene STARR-seq mESC enhancer starr_07092 Neighboring gene STARR-seq mESC enhancer starr_07093 Neighboring gene STARR-positive B cell enhancer mm9_chr3:19330305-19330606 Neighboring gene STARR-seq mESC enhancer starr_07094 Neighboring gene STARR-seq mESC enhancer starr_07095 Neighboring gene STARR-seq mESC enhancer starr_07096 Neighboring gene predicted gene, 23330 Neighboring gene STARR-seq mESC enhancer starr_07097 Neighboring gene B-cell leukemia/lymphoma 10 pseudogene Neighboring gene nuclear encoded tRNA arginine 3 (anticodon ACG) Neighboring gene nuclear encoded tRNA tyrosine 1 (anticodon GTA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain. Gundersen CB, et al. Brain Res, 2010 May 21. PMID 20338151
    2. Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays. Rodríguez-de la Rosa L, et al. Hear Res, 2015 Dec. PMID 26341476
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 5B
    Names
    CSP-beta
    DnaJ (Hsp40) homolog, subfamily C, member 5 beta
    beta cysteine string protein
    beta-CSP
    cysteine string protein beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163536.2 → NP_001157008.1  dnaJ homolog subfamily C member 5B

      See identical proteins and their annotated locations for NP_001157008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC141209, AC157815
      Consensus CDS
      CCDS17257.1
      UniProtKB/Swiss-Prot
      Q810R9, Q9CQ94
      Related
      ENSMUSP00000112849.2, ENSMUST00000118968.8
      Conserved Domains (1) summary
      COG0484
      Location:19 → 88
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_001163537.2 → NP_001157009.1  dnaJ homolog subfamily C member 5B

      See identical proteins and their annotated locations for NP_001157009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC141209, AC157815
      Consensus CDS
      CCDS17257.1
      UniProtKB/Swiss-Prot
      Q810R9, Q9CQ94
      Related
      ENSMUSP00000127515.2, ENSMUST00000165693.2
      Conserved Domains (1) summary
      COG0484
      Location:19 → 88
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    3. NM_025489.4 → NP_079765.3  dnaJ homolog subfamily C member 5B

      See identical proteins and their annotated locations for NP_079765.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC141209, AC157815
      Consensus CDS
      CCDS17257.1
      UniProtKB/Swiss-Prot
      Q810R9, Q9CQ94
      Related
      ENSMUSP00000029132.5, ENSMUST00000029132.11
      Conserved Domains (1) summary
      COG0484
      Location:19 → 88
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      19562755..19665026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535515.1 → XP_006535578.1  dnaJ homolog subfamily C member 5B isoform X1

      Conserved Domains (1) summary
      COG0484
      Location:19 → 88
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. XM_006535516.1 → XP_006535579.1  dnaJ homolog subfamily C member 5B isoform X1

      See identical proteins and their annotated locations for XP_006535579.1

      UniProtKB/Swiss-Prot
      Q810R9, Q9CQ94
      Conserved Domains (1) summary
      COG0484
      Location:19 → 88
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ94.1 GenPept UniProtKB/Swiss-Prot:Q9CQ94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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