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    Mocos molybdenum cofactor sulfurase [ Mus musculus (house mouse) ]

    Gene ID: 68591, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mocosprovided by MGI
    Official Full Name
    molybdenum cofactor sulfuraseprovided by MGI
    Primary source
    MGI:MGI:1915841
    See related
    Ensembl:ENSMUSG00000039616 AllianceGenome:MGI:1915841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCS; MOS; HMCS; 1110018O12Rik
    Summary
    Predicted to enable molybdenum cofactor sulfurtransferase activity. Involved in molybdopterin cofactor biosynthetic process. Is expressed in naris and olfactory epithelium. Used to study obstructive nephropathy and xanthinuria type II. Human ortholog(s) of this gene implicated in xanthinuria type II. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 11.8), small intestine adult (RPKM 5.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mocos in Genome Data Viewer
    Location:
    18 A2; 18 13.18 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24786538..24834634)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24653492..24701577)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8706 Neighboring gene solute carrier family 39 (metal ion transporter), member 6 Neighboring gene STARR-positive B cell enhancer mm9_chr18:24835661-24835962 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene formin homology 2 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_44073 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_44075 Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene expressed sequence AW554918

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice. Sedda D, et al. Kidney360, 2021 Nov 25. PMID 35372998, Free PMC Article
    2. Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. Ichida K, et al. Biochem Biophys Res Commun, 2001 Apr 20. PMID 11302742
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables molybdenum cofactor sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molybdopterin cofactor metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molybdopterin cofactor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in molybdopterin cofactor metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    molybdenum cofactor sulfurase
    Names
    moCo sulfurase
    molybdenum cofactor sulfurtransferase
    NP_081055.1
    XP_006526274.1
    XP_011245296.1
    XP_036017163.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026779.1 → NP_081055.1  molybdenum cofactor sulfurase

      See identical proteins and their annotated locations for NP_081055.1

      Status: PROVISIONAL

      Source sequence(s)
      BC113180
      Consensus CDS
      CCDS37750.1
      UniProtKB/Swiss-Prot
      Q14CH1
      Related
      ENSMUSP00000063609.8, ENSMUST00000068006.9
      Conserved Domains (4) summary
      PLN02724
      Location:28 → 854
      PLN02724; Molybdenum cofactor sulfurase
      pfam03473
      Location:720 → 852
      MOSC; MOSC domain
      pfam03476
      Location:572 → 688
      MOSC_N; MOSC N-terminal beta barrel domain
      cl18945
      Location:50 → 482
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      24786538..24834634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526211.5 → XP_006526274.1  molybdenum cofactor sulfurase isoform X1

      Conserved Domains (1) summary
      PLN02724
      Location:28 → 824
      PLN02724; Molybdenum cofactor sulfurase

    2. XM_011246994.4 → XP_011245296.1  molybdenum cofactor sulfurase isoform X2

      Conserved Domains (1) summary
      PLN02724
      Location:28 → 744
      PLN02724; Molybdenum cofactor sulfurase

    3. XM_036161270.1 → XP_036017163.1  molybdenum cofactor sulfurase isoform X3

      Related
      ENSMUST00000234253.2
      Conserved Domains (1) summary
      PLN02724
      Location:28 → 712
      PLN02724; Molybdenum cofactor sulfurase

    RNA

    1. XR_877139.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14CH1.1 GenPept UniProtKB/Swiss-Prot:Q14CH1

    Gene LinkOut

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