Cbx4 chromobox 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbx4provided by MGI
Official Full Name: chromobox 4provided by MGI
Primary source: MGI:MGI:1195985
See related: Ensembl:ENSMUSG00000039989 AllianceGenome:MGI:1195985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PC2; MPc2
Summary: Enables several functions, including SUMO binding activity; SUMO transferase activity; and nucleic acid binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and protein sumoylation. Located in nuclear body. Is expressed in several structures, including adrenal gland; brain; gut; lung; and thymus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CBX4 (chromobox 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 54.2), thymus adult (RPKM 19.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.34 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (118968399..118977067, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (119077571..119086237, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells.
Title: CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells.
Cbx4 governs HIF-1alpha to involve in Th9 cell differentiation promoting asthma by its SUMO E3 ligase activity.
Title: Cbx4 governs HIF-1α to involve in Th9 cell differentiation promoting asthma by its SUMO E3 ligase activity.
CBX4 deletion promotes tumorigenesis under Kras[G12D] background by inducing genomic instability.
Title: CBX4 deletion promotes tumorigenesis under Kras(G12D) background by inducing genomic instability.
Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells.
Title: Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells.
RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination.
Title: RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination.
Associations of genetic variation in E3 SUMO-protein ligase CBX4 with noise-induced hearing loss.
Title: Associations of genetic variation in E3 SUMO-protein ligase CBX4 with noise-induced hearing loss.
Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/beta-catenin pathway.
Title: Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway.
CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma.
Title: CBX4 transcriptionally suppresses KLF6 via interaction with HDAC1 to exert oncogenic activities in clear cell renal cell carcinoma.
Results identify a modifying enzyme for Prdm16, and they demonstrate a central role of Cbx4 in the control of Prdm16 stability and white fat browning.
Title: Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis.
The Cbx4 plays a crucial role in the p63-regulated program of epidermal differentiation, maintaining the epithelial identity and proliferative activity in KCs via repression of the selected nonepidermal lineage and cell cycle inhibitor genes.
Title: Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cbx4 (e-PCR), detects polymorphism
- UniSTS:515961

Cbx4 (e-PCR), detects polymorphism
- UniSTS:515962

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO binding	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO binding	IDA Inferred from Direct Assay more info	PubMed
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO ligase activity	IEA Inferred from Electronic Annotation more info
enables SUMO ligase activity	ISO Inferred from Sequence Orthology more info
enables SUMO transferase activity	EXP Inferred from Experiment more info	PubMed
enables SUMO transferase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: E3 SUMO-protein ligase CBX4

Names: E3 SUMO-protein transferase CBX4; chromobox homolog 4; chromobox protein homolog 4; polycomb 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.