Ccnd2 cyclin D2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnd2provided by MGI
Official Full Name: cyclin D2provided by MGI
Primary source: MGI:MGI:88314
See related: Ensembl:ENSMUSG00000000184 AllianceGenome:MGI:88314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cD2; Vin1; Vin-1; 2600016F06Rik
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Acts upstream of or within several processes, including adult locomotory behavior; cellular response to X-ray; and long-term memory. Located in nucleus. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; hepatitis B; and liver cancer (multiple). Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 77.3), limb E14.5 (RPKM 41.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.92 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (127102125..127131913, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (127125162..127152188, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of individualized behavioral trajectories in adult neurogenesis-deficient cyclin D2 knockout mice.
Title: Loss of individualized behavioral trajectories in adult neurogenesis-deficient cyclin D2 knockout mice.
CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.
Title: CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.
SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a.
Title: SRSF1 promotes ASMC proliferation in asthma by competitively binding CCND2 with miRNA-135a.
Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy.
Title: Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy.
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
Title: Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice.
Title: miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice.
Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
Title: Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
Testis-enriched circular RNA circ-Bbs9 plays an important role in Leydig cell proliferation by regulating a CyclinD2-dependent pathway.
Title: Testis-enriched circular RNA circ-Bbs9 plays an important role in Leydig cell proliferation by regulating a CyclinD2-dependent pathway.
Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation.
Title: Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation.
E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of cardiomyocyte.
Title: Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235558

NoName (e-PCR)
- UniSTS:548206

Ccnd2 (e-PCR), detects polymorphism
- UniSTS:531328

C86853 (e-PCR)
- UniSTS:208030

Ccnd2 (e-PCR), detects polymorphism
- UniSTS:506785

RH136101 (e-PCR)
- UniSTS:210096

Ccnd2 (e-PCR), detects polymorphism
- UniSTS:141257

Ccnd2 (e-PCR), detects polymorphism
- UniSTS:141258

UniSTS:141259 (e-PCR)
- UniSTS:141259

Ccnd2 (e-PCR), detects polymorphism
- UniSTS:141259

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of cyclin D2-CDK4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin D2-CDK4 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G1/S-specific cyclin-D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009829.3 → NP_033959.1 G1/S-specific cyclin-D2

See identical proteins and their annotated locations for NP_033959.1

Status: VALIDATED

Source sequence(s)

AK147345, BY161742, CAAA01200960

Consensus CDS

CCDS20564.1

UniProtKB/Swiss-Prot

P30280

UniProtKB/TrEMBL

Q4FK45

Related

ENSMUSP00000000188.9, ENSMUST00000000188.12

Conserved Domains (2) summary

pfam00134
Location:24 → 151

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:153 → 262

Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

127102125..127131913 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165787.1 → XP_036021680.1 G1/S-specific cyclin-D2 isoform X2

Conserved Domains (2) summary

cd20574
Location:48 → 196

CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)

cd20577
Location:201 → 305

CYCLIN_CCND2_rpt2; second cyclin box found in G1/S-specific cyclin-D2 (CCND2)
XM_036165785.1 → XP_036021678.1 G1/S-specific cyclin-D2 isoform X1

Conserved Domains (2) summary

cd20574
Location:61 → 209

CYCLIN_CCND2_rpt1; first cyclin box found in G1/S-specific cyclin-D2 (CCND2)

cd20577
Location:214 → 318

CYCLIN_CCND2_rpt2; second cyclin box found in G1/S-specific cyclin-D2 (CCND2)
XM_036165786.1 → XP_036021679.1 G1/S-specific cyclin-D2 isoform X2
XM_006505460.1 → XP_006505523.1 G1/S-specific cyclin-D2 isoform X3

See identical proteins and their annotated locations for XP_006505523.1

UniProtKB/Swiss-Prot

P30280

UniProtKB/TrEMBL

Q4FK45

Conserved Domains (2) summary

pfam00134
Location:24 → 151

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:153 → 262

Cyclin_C; Cyclin, C-terminal domain
XM_006505459.3 → XP_006505522.1 G1/S-specific cyclin-D2 isoform X3

See identical proteins and their annotated locations for XP_006505522.1

UniProtKB/Swiss-Prot

P30280

UniProtKB/TrEMBL

Q4FK45

Conserved Domains (2) summary

pfam00134
Location:24 → 151

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:153 → 262

Cyclin_C; Cyclin, C-terminal domain
XM_036165788.1 → XP_036021681.1 G1/S-specific cyclin-D2 isoform X4
XM_036165789.1 → XP_036021682.1 G1/S-specific cyclin-D2 isoform X5