Dnm1l dynamin 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnm1lprovided by MGI
Official Full Name: dynamin 1-likeprovided by MGI
Primary source: MGI:MGI:1921256
See related: Ensembl:ENSMUSG00000022789 AllianceGenome:MGI:1921256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlp1; Drp1; Dnmlp1; python; 6330417M19Rik
Summary: This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]
Expression: Broad expression in cerebellum adult (RPKM 25.5), CNS E18 (RPKM 24.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A2; 16 10.12 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16130092..16176863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16312228..16359038, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission.
Title: Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission.
Mechanistic insights into metabolic function of dynamin-related protein 1.
Title: Mechanistic insights into metabolic function of dynamin-related protein 1.
SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner.
Title: SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner.
Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis.
Title: Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis.
lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation.
Title: lncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation.
MCU inhibition protects against intestinal ischemia-reperfusion by inhibiting Drp1-dependent mitochondrial fission.
Title: MCU inhibition protects against intestinal ischemia‒reperfusion by inhibiting Drp1-dependent mitochondrial fission.
MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.
Title: MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.
GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy.
Title: GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy.
Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.
Title: Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function.
Title: A partial Drp1 knockout improves autophagy flux independent of mitochondrial function.

Submit: New GeneRIF Correction See all GeneRIFs (220)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH2 domain binding	IEA Inferred from Electronic Annotation more info
enables BH2 domain binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipid	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	IEA Inferred from Electronic Annotation more info
involved_in intracellular distribution of mitochondria	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fragmentation involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial membrane fission	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial membrane fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peroxisome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to flavonoid	IEA Inferred from Electronic Annotation more info
involved_in response to hypobaric hypoxia	IEA Inferred from Electronic Annotation more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle recycling via endosome	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle recycling via endosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion-derived vesicle	IEA Inferred from Electronic Annotation more info
colocalizes_with mitochondrion-derived vesicle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in presynaptic endocytic zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynamin-1-like protein

Names: dymple; dynamin family member proline-rich carboxyl-terminal domain less; dynamin-related protein 1

NP_001021118.1

EC 3.6.5.5

NP_001263269.1

EC 3.6.5.5

NP_001263270.1

EC 3.6.5.5

NP_001346936.1

EC 3.6.5.5

NP_001346937.1

EC 3.6.5.5

NP_001346938.1

EC 3.6.5.5

NP_001346939.1

EC 3.6.5.5

NP_001392181.1

EC 3.6.5.5

NP_001392182.1

EC 3.6.5.5

NP_001392183.1

EC 3.6.5.5

NP_001392184.1

EC 3.6.5.5

NP_001392185.1

EC 3.6.5.5

NP_001392186.1

EC 3.6.5.5

NP_001392187.1

EC 3.6.5.5

NP_001392188.1

EC 3.6.5.5

NP_001392189.1

EC 3.6.5.5

NP_001392190.1

EC 3.6.5.5

NP_001392191.1

EC 3.6.5.5

NP_001392192.1

EC 3.6.5.5

NP_001392193.1

EC 3.6.5.5

NP_001392194.1

EC 3.6.5.5

NP_690029.2

EC 3.6.5.5

XP_006522701.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025947.3 → NP_001021118.1 dynamin-1-like protein isoform b

See identical proteins and their annotated locations for NP_001021118.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (b) is shorter than isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS27984.1

UniProtKB/TrEMBL

Q3U4P3

Related

ENSMUSP00000023477.8, ENSMUST00000023477.15

Conserved Domains (4) summary

cd08771
Location:23 → 302

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:88 → 692

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:227 → 510

Dynamin_M; Dynamin central region

pfam02212
Location:605 → 693

GED; Dynamin GTPase effector domain
NM_001276340.2 → NP_001263269.1 dynamin-1-like protein isoform c

See identical proteins and their annotated locations for NP_001263269.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (c) is shorter than isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS70689.1

UniProtKB/TrEMBL

Q3U4P3

Related

ENSMUSP00000155155.2, ENSMUST00000230980.2

Conserved Domains (4) summary

cd08771
Location:23 → 308

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:94 → 709

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:233 → 516

Dynamin_M; Dynamin central region

pfam02212
Location:622 → 710

GED; Dynamin GTPase effector domain
NM_001276341.2 → NP_001263270.1 dynamin-1-like protein isoform d

See identical proteins and their annotated locations for NP_001263270.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate 5' structure, has multiple differences in the coding region and initiates translation at a downstream start codon, compared to variant 6. It encodes isoform d which has a shorter N-terminus compared to isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS88885.1

UniProtKB/TrEMBL

Q3U4P3

Related

ENSMUSP00000155429.2, ENSMUST00000230022.2

Conserved Domains (4) summary

cd08771
Location:3 → 204

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:1 → 605

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:129 → 412

Dynamin_M; Dynamin central region

pfam02212
Location:518 → 606

GED; Dynamin GTPase effector domain
NM_001360007.2 → NP_001346936.1 dynamin-1-like protein isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (e).

Source sequence(s)

AC112943

UniProtKB/TrEMBL

Q3U4P3

Conserved Domains (3) summary

cd08771
Location:23 → 321

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:245 → 528

Dynamin_M; Dynamin central region

pfam02212
Location:661 → 749

GED; Dynamin GTPase effector domain
NM_001360008.2 → NP_001346937.1 dynamin-1-like protein isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (f) is shorter than isoform e.

Source sequence(s)

AC112943

UniProtKB/TrEMBL

Q3U4P3

Conserved Domains (3) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:239 → 522

Dynamin_M; Dynamin central region

pfam02212
Location:655 → 743

GED; Dynamin GTPase effector domain
NM_001360009.2 → NP_001346938.1 dynamin-1-like protein isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (g) is shorter than isoform e.

Source sequence(s)

AC112943

UniProtKB/TrEMBL

Q3U4P3

Conserved Domains (3) summary

cd08771
Location:23 → 321

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:245 → 528

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 738

GED; Dynamin GTPase effector domain
NM_001360010.2 → NP_001346939.1 dynamin-1-like protein isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (h) is shorter than isoform e.

Source sequence(s)

AC112943

UniProtKB/TrEMBL

Q3U4P3

Conserved Domains (3) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:239 → 522

Dynamin_M; Dynamin central region

pfam02212
Location:629 → 717

GED; Dynamin GTPase effector domain
NM_001405252.1 → NP_001392181.1 dynamin-1-like protein isoform d

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405253.1 → NP_001392182.1 dynamin-1-like protein isoform i

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405254.1 → NP_001392183.1 dynamin-1-like protein isoform j

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405255.1 → NP_001392184.1 dynamin-1-like protein isoform k

Status: REVIEWED

Source sequence(s)

AC112943

UniProtKB/Swiss-Prot

E9PUD2, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1, Q8K1M6
NM_001405256.1 → NP_001392185.1 dynamin-1-like protein isoform l

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405257.1 → NP_001392186.1 dynamin-1-like protein isoform m

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405258.1 → NP_001392187.1 dynamin-1-like protein isoform n

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405259.1 → NP_001392188.1 dynamin-1-like protein isoform o

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405260.1 → NP_001392189.1 dynamin-1-like protein isoform p

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405261.1 → NP_001392190.1 dynamin-1-like protein isoform q

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405262.1 → NP_001392191.1 dynamin-1-like protein isoform r

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405263.1 → NP_001392192.1 dynamin-1-like protein isoform s

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405264.1 → NP_001392193.1 dynamin-1-like protein isoform t

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405265.1 → NP_001392194.1 dynamin-1-like protein isoform t

Status: REVIEWED

Source sequence(s)

AC112943
NM_152816.4 → NP_690029.2 dynamin-1-like protein isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (a) is shorter than isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS27985.1

UniProtKB/TrEMBL

Q3U4P3

Related

ENSMUSP00000093945.4, ENSMUST00000096229.11

Conserved Domains (4) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:101 → 705

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:240 → 523

Dynamin_M; Dynamin central region

pfam02212
Location:618 → 706

GED; Dynamin GTPase effector domain

RNA

NR_075074.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences, compared to variant 6. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC112943
NR_175921.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175922.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175923.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175924.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175925.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175926.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175927.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175928.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175929.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175930.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175931.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175932.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175933.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

16130092..16176863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522638.5 → XP_006522701.1 dynamin-1-like protein isoform X9

UniProtKB/TrEMBL

A0A2U3TZ67, Q3U4P3

Related

ENSMUSP00000111415.3, ENSMUST00000115749.3

Conserved Domains (3) summary

cd08771
Location:1 → 153

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:77 → 361

Dynamin_M; Dynamin central region

pfam02212
Location:492 → 581

GED; Dynamin GTPase effector domain