Spata20 spermatogenesis associated 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spata20provided by MGI
Official Full Name: spermatogenesis associated 20provided by MGI
Primary source: MGI:MGI:2183449
See related: Ensembl:ENSMUSG00000020867 AllianceGenome:MGI:2183449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tisp78
Summary: Predicted to be involved in carbohydrate metabolic process; cell differentiation; and spermatogenesis. Predicted to be located in extracellular region. Used to study oligoasthenoteratozoospermia. Orthologous to human SPATA20 (spermatogenesis associated 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 496.0) See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 58.9 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94369730..94376136, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (94478904..94485310, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBalpha.
Title: Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBα.
The role of SPATA2 in TNF signaling, cancer, and spermatogenesis.
Title: The role of SPATA2 in TNF signaling, cancer, and spermatogenesis.
Ssp411 mRNA and protein were detected exclusively in spermatids after step 9 during spermiogenesis in testis. Males are sterile in an Ssp411 expression-disrupted murine strain (Ssp411(PB/PB)). Ssp411 participates in the ubiquitin-proteasome system by interacting with PSMC3. Ssp411 is required for spermatogenesis and plays a role in sperm head shaping.
Title: Disruption of Ssp411 causes impaired sperm head formation and male sterility in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Transposon induced (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spermatogenesis-associated protein 20

Names: sperm protein SSP411; sperm-specific protein 411; ssp411; transcript increased in spermiogenesis 78 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144827.4 → NP_659076.2 spermatogenesis-associated protein 20

See identical proteins and their annotated locations for NP_659076.2

Status: VALIDATED

Source sequence(s)

BC050788

Consensus CDS

CCDS25256.1

UniProtKB/Swiss-Prot

Q80YT5

Related

ENSMUSP00000042572.8, ENSMUST00000041705.8

Conserved Domains (3) summary

COG1331
Location:59 → 788

YyaL; Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains [General function prediction only]

pfam03190
Location:67 → 227

Thioredox_DsbH; Protein of unknown function, DUF255

pfam06202
Location:595 → 637

GDE_C; Amylo-alpha-1,6-glucosidase