Osm oncostatin M [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Osmprovided by MGI
Official Full Name: oncostatin Mprovided by MGI
Primary source: MGI:MGI:104749
See related: Ensembl:ENSMUSG00000058755 AllianceGenome:MGI:104749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OncoM
Summary: Enables cytokine activity. Acts upstream of or within several processes, including negative regulation of meiotic nuclear division; positive regulation of peptidyl-tyrosine phosphorylation; and tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in several structures, including aorta-gonad-mesonephros; future spinal cord; genitourinary system; submandibular gland; and trophectoderm. Orthologous to human OSM (oncostatin M). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 1.9), thymus adult (RPKM 1.8) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.94 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (4186831..4191027)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (4236785..4241026)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncostatin M signaling drives cancer-associated skeletal muscle wasting.
Title: Oncostatin M signaling drives cancer-associated skeletal muscle wasting.
Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic Systems.
Title: Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic Systems.
Network-based cytokine inference implicates Oncostatin M as a driver of an inflammation phenotype in knee osteoarthritis.
Title: Network-based cytokine inference implicates Oncostatin M as a driver of an inflammation phenotype in knee osteoarthritis.
Oncostatin M Reduces Pathological Neovascularization in the Retina Through Muller Cell Activation.
Title: Oncostatin M Reduces Pathological Neovascularization in the Retina Through Müller Cell Activation.
Oncostatin M regulates macrophages polarization in osseointegration via yes-associated protein.
Title: Oncostatin M regulates macrophages polarization in osseointegration via yes-associated protein.
Loss of Hematopoietic Cell-Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice.
Title: Loss of Hematopoietic Cell-Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice.
Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
Title: Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.
Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator.
Title: Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator.
Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment.
Title: Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment.
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling.
Title: Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

PMC156147P5 (e-PCR)
- UniSTS:271382

Osm (e-PCR), detects polymorphism
- UniSTS:256375

NoName (e-PCR)
- UniSTS:489598

D31942 (e-PCR)
- UniSTS:180143

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables oncostatin-M receptor binding	IEA Inferred from Electronic Annotation more info
enables oncostatin-M receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of meiotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
involved_in oncostatin-M-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oncostatin-M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.