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    Rnf216 ring finger protein 216 [ Mus musculus (house mouse) ]

    Gene ID: 108086, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf216provided by MGI
    Official Full Name
    ring finger protein 216provided by MGI
    Primary source
    MGI:MGI:1344349
    See related
    Ensembl:ENSMUSG00000045078 AllianceGenome:MGI:1344349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UIP83; TRIAD3; Ubce7ip1; 2810055G22Rik; F830018F18Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein K48-linked ubiquitination; protein catabolic process, modulating synaptic transmission; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.7), adrenal adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnf216 in Genome Data Viewer
    Location:
    5 G2; 5 81.86 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142976648..143098793, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142990893..143113041, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6395 Neighboring gene STARR-positive B cell enhancer ABC_E674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143670916-143671255 Neighboring gene predicted gene, 38733 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143682513-143682666 Neighboring gene actin, beta Neighboring gene STARR-seq mESC enhancer starr_14775 Neighboring gene STARR-seq mESC enhancer starr_14777 Neighboring gene fascin actin-bundling protein 1 Neighboring gene STARR-seq mESC enhancer starr_14779 Neighboring gene VISTA enhancer mm1619 Neighboring gene predicted gene 43380 Neighboring gene STARR-seq mESC enhancer starr_14782 Neighboring gene STARR-seq mESC enhancer starr_14783 Neighboring gene STARR-positive B cell enhancer ABC_E3631 Neighboring gene STARR-seq mESC enhancer starr_14784 Neighboring gene nonconserved acetylation island sequence M61 enhancer Neighboring gene olfactory receptor family 10 subfamily AH member 1, pseudogene 1 Neighboring gene predicted gene, 38734 Neighboring gene STARR-seq mESC enhancer starr_14788 Neighboring gene predicted gene 7291

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein catabolic process, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of defense response to virus by host ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic endocytic zone IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic endocytic zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF216
    Names
    E3 ubiquitin ligase
    RING-type E3 ubiquitin transferase RNF216
    triad domain-containing protein 3
    ubcM4-interacting protein 83
    ubiquitin-conjugating enzyme 7-interacting protein 1
    NP_001346780.1
    NP_542128.2
    NP_996993.1
    XP_006504707.1
    XP_006504708.1
    XP_006504709.1
    XP_017176080.1
    XP_017176081.1
    XP_017176082.1
    XP_030109902.1
    XP_036020615.1
    XP_036020616.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359851.1NP_001346780.1  E3 ubiquitin-protein ligase RNF216 isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C) differs in the 5' UTR and coding sequence compared to variant B. The resulting isoform (C) is shorter at the N-terminus compared to isoform B.
      Source sequence(s)
      AC113281
      Conserved Domains (1) summary
      cd16630
      Location:310366
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    2. NM_080561.4NP_542128.2  E3 ubiquitin-protein ligase RNF216 isoform A

      See identical proteins and their annotated locations for NP_542128.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) uses an alternate in-frame splice junction compared to variant B. The resulting isoform (A) has the same N- and C-termini but is shorter compared to isoform B.
      Source sequence(s)
      BB854046, BC065066
      Consensus CDS
      CCDS80455.1
      UniProtKB/Swiss-Prot
      P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3
      Related
      ENSMUSP00000052563.10, ENSMUST00000053498.13
      Conserved Domains (2) summary
      cd16630
      Location:501557
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:643693
      IBR; IBR domain, a half RING-finger domain
    3. NM_207110.1NP_996993.1  E3 ubiquitin-protein ligase RNF216 isoform B

      See identical proteins and their annotated locations for NP_996993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) represents the longest transcript and encodes the longest isoform (B).
      Source sequence(s)
      AC113281, AK147861, BB854046, BC065066
      Consensus CDS
      CCDS57400.1
      UniProtKB/Swiss-Prot
      P58283
      Related
      ENSMUSP00000143705.2, ENSMUST00000200607.5
      Conserved Domains (2) summary
      cd16630
      Location:558614
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:700750
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142976648..143098793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254042.1XP_030109902.1  E3 ubiquitin-protein ligase RNF216 isoform X4

      Conserved Domains (2) summary
      cd16630
      Location:416472
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:558608
      IBR; IBR domain, a half RING-finger domain
    2. XM_006504646.4XP_006504709.1  E3 ubiquitin-protein ligase RNF216 isoform X3

      Conserved Domains (2) summary
      cd16630
      Location:473529
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:615665
      IBR; IBR domain, a half RING-finger domain
    3. XM_006504644.5XP_006504707.1  E3 ubiquitin-protein ligase RNF216 isoform X1

      See identical proteins and their annotated locations for XP_006504707.1

      UniProtKB/Swiss-Prot
      P58283
      Conserved Domains (2) summary
      cd16630
      Location:558614
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:700750
      IBR; IBR domain, a half RING-finger domain
    4. XM_006504645.5XP_006504708.1  E3 ubiquitin-protein ligase RNF216 isoform X2

      See identical proteins and their annotated locations for XP_006504708.1

      UniProtKB/Swiss-Prot
      P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3
      Conserved Domains (2) summary
      cd16630
      Location:501557
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:643693
      IBR; IBR domain, a half RING-finger domain
    5. XM_017320593.3XP_017176082.1  E3 ubiquitin-protein ligase RNF216 isoform X5

      Conserved Domains (1) summary
      cd16630
      Location:310366
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    6. XM_017320592.3XP_017176081.1  E3 ubiquitin-protein ligase RNF216 isoform X5

      Conserved Domains (1) summary
      cd16630
      Location:310366
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
    7. XM_036164722.1XP_036020615.1  E3 ubiquitin-protein ligase RNF216 isoform X1

      Conserved Domains (2) summary
      cd16630
      Location:558614
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:700750
      IBR; IBR domain, a half RING-finger domain
    8. XM_017320591.3XP_017176080.1  E3 ubiquitin-protein ligase RNF216 isoform X1

      UniProtKB/Swiss-Prot
      P58283
      Conserved Domains (2) summary
      cd16630
      Location:558614
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:700750
      IBR; IBR domain, a half RING-finger domain
    9. XM_036164723.1XP_036020616.1  E3 ubiquitin-protein ligase RNF216 isoform X2

      UniProtKB/Swiss-Prot
      P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3
      Conserved Domains (2) summary
      cd16630
      Location:501557
      RING-HC_RBR_RNF216; RING finger, HC subclass, found in RING finger protein 216 (RNF216) and similar proteins
      pfam01485
      Location:643693
      IBR; IBR domain, a half RING-finger domain