Uba6 ubiquitin-like modifier activating enzyme 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uba6provided by MGI
Official Full Name: ubiquitin-like modifier activating enzyme 6provided by MGI
Primary source: MGI:MGI:1913894
See related: Ensembl:ENSMUSG00000035898 AllianceGenome:MGI:1913894
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E1-L2; Ube1l2; 4930542H01; 5730469D23Rik
Summary: Enables FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including dendritic spine development; learning; and limbic system development. Predicted to be active in cytoplasm. Is expressed in cerebral cortex and gonad. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 8.1), CNS E11.5 (RPKM 4.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86258579..86320602, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86110720..86172743, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses.
Title: Inhibition of UBA6 by inosine augments tumour immunogenicity and responses.
Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation.
Title: Ubiquitin Activating Enzyme UBA6 Regulates Th1 and Tc1 Cell Differentiation.
Early-stage paired housing improves social interaction in neuronal Uba6-deficient mice as a model of autism spectrum disorder.
Title: Early-stage paired housing improves social interaction in neuronal Uba6-deficient mice.
Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro.
Title: Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.
The identification of an E1-like protein, termed E1-L2, that activates both ubiquitin and another ubiquitin-like protein, FAT10, is reported.
Title: E1-L2 activates both ubiquitin and FAT10.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Uba6 (e-PCR), detects polymorphism
- UniSTS:548032

NoName (e-PCR)
- UniSTS:235205

NoName (e-PCR)
- UniSTS:235207

BB446153 (e-PCR)
- UniSTS:207824

AU021846 (e-PCR)
- UniSTS:207825

AW124799 (e-PCR)
- UniSTS:179192

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables FAT10 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables FAT10 activating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables FAT10 activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin activating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amygdala development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme 6

Names: ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; ubiquitin-activating enzyme E1-like protein 2

NP_766300.1

EC 6.2.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172712.2 → NP_766300.1 ubiquitin-like modifier-activating enzyme 6

See identical proteins and their annotated locations for NP_766300.1

Status: PROVISIONAL

Source sequence(s)

BC063048

Consensus CDS

CCDS19378.1

UniProtKB/Swiss-Prot

Q8C7R4

UniProtKB/TrEMBL

D3Z061

Related

ENSMUSP00000035328.8, ENSMUST00000039373.14

Conserved Domains (4) summary

cd01490
Location:462 → 1005

Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...

cd01491
Location:43 → 432

Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...

TIGR01408
Location:38 → 1046

Ube1; ubiquitin-activating enzyme E1

pfam16191
Location:299 → 362

E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle