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    Klc3 kinesin light chain 3 [ Mus musculus (house mouse) ]

    Gene ID: 232943, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klc3provided by MGI
    Official Full Name
    kinesin light chain 3provided by MGI
    Primary source
    MGI:MGI:1277971
    See related
    Ensembl:ENSMUSG00000040714 AllianceGenome:MGI:1277971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klct
    Summary
    Enables kinesin binding activity and microtubule binding activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within axo-dendritic transport. Located in several cellular components, including ciliary rootlet; mitochondrion; and motile cilium. Is expressed in cerebellum interpositus nucleus; deep cerebellar nucleus; dentate nucleus; fastigial nucleus; and vestibular nucleus. Orthologous to human KLC3 (kinesin light chain 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 20.6), testis adult (RPKM 14.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klc3 in Genome Data Viewer
    Location:
    7 A3; 7 9.62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19128365..19138101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19394440..19404174, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6519 Neighboring gene protein phosphatase 1, regulatory subunit 13 like Neighboring gene STARR-seq mESC enhancer starr_18201 Neighboring gene STARR-positive B cell enhancer mm9_chr7:19967137-19967438 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 2 Neighboring gene microRNA 343 Neighboring gene predicted gene, 38954 Neighboring gene RIKEN cDNA A930016O22 gene Neighboring gene creatine kinase, muscle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†. Daniel-Carlier N, et al. Biol Reprod, 2024 Jan 13. PMID 37776549
    2. KLC3 is involved in sperm tail midpiece formation and sperm function. Zhang Y, et al. Dev Biol, 2012 Jun 15. PMID 22561200
    3. Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality. de Boer J, et al. Cancer Res, 1998 Jan 1. PMID 9426063
    4. KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease. Rah G, et al. J Am Soc Nephrol, 2022 Sep. PMID 35961787, Free PMC Article
    5. Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Lamerdin JE, et al. Genomics, 1996 Jun 15. PMID 8786141

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertilitydagger.
      Title: Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†.
    2. KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.
      Title: KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.
    3. KLC3 plays a role during spermiogenesis in the development of the midpiece and in the normal function of spermatozoa
      Title: KLC3 is involved in sperm tail midpiece formation and sperm function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28837

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intraciliary transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm mitochondrial sheath assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary rootlet IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin light chain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286038.2 → NP_001272967.1  kinesin light chain 3 isoform a

      See identical proteins and their annotated locations for NP_001272967.1

      Status: VALIDATED

      Source sequence(s)
      AC118017
      Consensus CDS
      CCDS20901.1
      UniProtKB/Swiss-Prot
      Q3TZ56, Q91W40
      UniProtKB/TrEMBL
      D3Z710
      Related
      ENSMUSP00000038091.4, ENSMUST00000047170.10
      Conserved Domains (4) summary
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:375 → 403
      TPR_1; Tetratricopeptide repeat
      pfam13374
      Location:290 → 331
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:245 → 323
      TPR_12; Tetratricopeptide repeat

    2. NM_001286039.2 → NP_001272968.1  kinesin light chain 3 isoform a

      See identical proteins and their annotated locations for NP_001272968.1

      Status: VALIDATED

      Source sequence(s)
      AC118017
      Consensus CDS
      CCDS20901.1
      UniProtKB/Swiss-Prot
      Q3TZ56, Q91W40
      UniProtKB/TrEMBL
      D3Z710
      Related
      ENSMUSP00000104098.4, ENSMUST00000108458.10
      Conserved Domains (4) summary
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:375 → 403
      TPR_1; Tetratricopeptide repeat
      pfam13374
      Location:290 → 331
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:245 → 323
      TPR_12; Tetratricopeptide repeat

    3. NM_001403685.1 → NP_001390614.1  kinesin light chain 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC118017
      Related
      ENSMUSP00000104097.2, ENSMUST00000108457.3

    4. NM_146182.5 → NP_666294.1  kinesin light chain 3 isoform a

      See identical proteins and their annotated locations for NP_666294.1

      Status: VALIDATED

      Source sequence(s)
      AC118017
      Consensus CDS
      CCDS20901.1
      UniProtKB/Swiss-Prot
      Q3TZ56, Q91W40
      UniProtKB/TrEMBL
      D3Z710
      Related
      ENSMUSP00000104099.3, ENSMUST00000108459.9
      Conserved Domains (4) summary
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:375 → 403
      TPR_1; Tetratricopeptide repeat
      pfam13374
      Location:290 → 331
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:245 → 323
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19128365..19138101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242434.2 → XP_030098294.1  kinesin light chain 3 isoform X4

      UniProtKB/TrEMBL
      D3Z710
      Conserved Domains (3) summary
      TIGR02168
      Location:21 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:247 → 323
      TPR_12; Tetratricopeptide repeat

    2. XM_030242432.1 → XP_030098292.1  kinesin light chain 3 isoform X1

      UniProtKB/TrEMBL
      D3Z710
      Conserved Domains (3) summary
      TIGR02168
      Location:26 → 153
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:296 → 324
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:252 → 328
      TPR_12; Tetratricopeptide repeat

    3. XM_017322153.2 → XP_017177642.1  kinesin light chain 3 isoform X2

      UniProtKB/TrEMBL
      D3Z710
      Conserved Domains (3) summary
      TIGR02168
      Location:26 → 153
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:296 → 324
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:252 → 328
      TPR_12; Tetratricopeptide repeat

    4. XM_030242435.2 → XP_030098295.1  kinesin light chain 3 isoform X4

      UniProtKB/TrEMBL
      D3Z710
      Conserved Domains (3) summary
      TIGR02168
      Location:21 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:291 → 319
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:247 → 323
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W40.1 GenPept UniProtKB/Swiss-Prot:Q91W40

    Gene LinkOut

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