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    Gatd3a glutamine amidotransferase like class 1 domain containing 3A [ Mus musculus (house mouse) ]

    Gene ID: 28295, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gatd3aprovided by MGI
    Official Full Name
    glutamine amidotransferase like class 1 domain containing 3Aprovided by MGI
    Primary source
    MGI:MGI:1351861
    See related
    Ensembl:ENSMUSG00000053329 AllianceGenome:MGI:1351861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ES1; Gatd3; C21orf33; D10Jhu81e
    Summary
    Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human GATD3 (glutamine amidotransferase class 1 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 190.1), heart adult (RPKM 107.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gatd3a in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77997900..78005589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78162066..78169755, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51775 Neighboring gene icos ligand Neighboring gene STARR-positive B cell enhancer ABC_E5152 Neighboring gene STARR-positive B cell enhancer ABC_E6876 Neighboring gene STARR-positive B cell enhancer ABC_E2328 Neighboring gene predicted gene, 47922 Neighboring gene STARR-positive B cell enhancer ABC_E6877 Neighboring gene STARR-seq mESC enhancer starr_27217 Neighboring gene PWP2 periodic tryptophan protein homolog (yeast) Neighboring gene trafficking protein particle complex 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration. Kretschmer V, et al. PLoS Biol, 2023 Dec. PMID 38048369, Free PMC Article
    2. Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Manning JA, et al. Histochem Cell Biol, 2008 Jun. PMID 18239929
    3. Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation. Patnaik SR, et al. Cell Mol Life Sci, 2019 Feb. PMID 30446775, Free PMC Article
    4. Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Wiltshire T, et al. Genome Res, 1999 Dec. PMID 10613844, Free PMC Article
    5. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial
    Names
    ES1 protein homolog, mitochondrial
    glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364646.1 → NP_001351575.1  glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC164573
      UniProtKB/TrEMBL
      A0A1W2P7B6
      Related
      ENSMUSP00000151605.2, ENSMUST00000219120.2
      Conserved Domains (1) summary
      cl00020
      Location:43 → 233
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    2. NM_138601.3 → NP_613067.1  glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_613067.1

      Status: VALIDATED

      Source sequence(s)
      AI852165, AK003866
      Consensus CDS
      CCDS35957.1
      UniProtKB/Swiss-Prot
      Q9D172
      Related
      ENSMUSP00000001242.8, ENSMUST00000001242.9
      Conserved Domains (1) summary
      cd03133
      Location:43 → 264
      GATase1_ES1; Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77997900..78005589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D172.1 GenPept UniProtKB/Swiss-Prot:Q9D172

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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