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    Osbpl3 oxysterol binding protein-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 71720, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osbpl3provided by MGI
    Official Full Name
    oxysterol binding protein-like 3provided by MGI
    Primary source
    MGI:MGI:1918970
    See related
    Ensembl:ENSMUSG00000029822 AllianceGenome:MGI:1918970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORP3; ORP-3; OSBP3; A530055M08; 1200014M06Rik; 6720421I08Rik
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in endoplasmic reticulum membrane and filopodium tip. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; immune system; olfactory epithelium; and respiratory system. Orthologous to human OSBPL3 (oxysterol binding protein like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 12.7), kidney adult (RPKM 6.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl3 in Genome Data Viewer
    Location:
    6 B2.3; 6 24.13 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (50270307..50433334, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (50293327..50456354, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15840 Neighboring gene predicted gene, 38805 Neighboring gene STARR-seq mESC enhancer starr_15842 Neighboring gene protein associated with LIN7 2, MAGUK family member Neighboring gene STARR-seq mESC enhancer starr_15843 Neighboring gene gasdermin E Neighboring gene STARR-positive B cell enhancer mm9_chr6:50244177-50244478 Neighboring gene STARR-seq mESC enhancer starr_15846 Neighboring gene STARR-positive B cell enhancer ABC_E8102 Neighboring gene STARR-seq mESC enhancer starr_15847 Neighboring gene predicted gene, 52900 Neighboring gene predicted gene, 40372 Neighboring gene predicted gene, 53324

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics. Wang X, et al. Cell Mol Life Sci, 2023 Sep 22. PMID 37740130, Free PMC Article
    2. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor. Njeru SN, et al. Oncogene, 2020 Feb. PMID 31659255
    3. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Yan D, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17303778
    4. Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease. Aibara D, et al. Mol Cell Endocrinol, 2023 Apr 5. PMID 36781118
    5. During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes. Revil T, et al. Dev Dyn, 2013 Mar. PMID 23233200

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
      Title: Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
    2. Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor gamma in fatty liver disease.
      Title: Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.
    3. OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.
      Title: Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102333

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 3
    Names
    OSBP-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163645.1 → NP_001157117.1  oxysterol-binding protein-related protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA086565, AK004768, AK040984, AK042104, AK160310, BX524424, CD538704, CF751761
      Consensus CDS
      CCDS51771.1
      UniProtKB/TrEMBL
      F8WH20, Q80UX3
      Related
      ENSMUSP00000071643.5, ENSMUST00000071728.11
      Conserved Domains (3) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:51 → 141
      PH; PH domain
      pfam01237
      Location:459 → 793
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001347213.1 → NP_001334142.1  oxysterol-binding protein-related protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008160, AC124689
      Consensus CDS
      CCDS85046.1
      UniProtKB/TrEMBL
      D3YTT6, Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_027881.3 → NP_082157.2  oxysterol-binding protein-related protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA086565, AK004768, AK040984, AK042104, BX524424, CD538704, CF751761
      Consensus CDS
      CCDS39489.1
      UniProtKB/Swiss-Prot
      E9QNI5, Q9DBS9
      UniProtKB/TrEMBL
      Q80UX3
      Related
      ENSMUSP00000110112.3, ENSMUST00000114468.9
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:495 → 839
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      50270307..50433334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255598.1 → XP_030111458.1  oxysterol-binding protein-related protein 3 isoform X3

      UniProtKB/TrEMBL
      D3Z194, Q80UX3
      Related
      ENSMUSP00000110110.2, ENSMUST00000114466.8
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:490 → 834
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_006506630.3 → XP_006506693.1  oxysterol-binding protein-related protein 3 isoform X1

      UniProtKB/TrEMBL
      D3YTT6, Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_006506633.5 → XP_006506696.1  oxysterol-binding protein-related protein 3 isoform X2

      UniProtKB/Swiss-Prot
      E9QNI5, Q9DBS9
      UniProtKB/TrEMBL
      Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:495 → 839
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_006506634.5 → XP_006506697.1  oxysterol-binding protein-related protein 3 isoform X3

      UniProtKB/TrEMBL
      D3Z194, Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:490 → 834
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_030255597.2 → XP_030111457.1  oxysterol-binding protein-related protein 3 isoform X3

      UniProtKB/TrEMBL
      D3Z194, Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:490 → 834
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_011241468.4 → XP_011239770.1  oxysterol-binding protein-related protein 3 isoform X1

      UniProtKB/TrEMBL
      D3YTT6, Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_006506635.4 → XP_006506698.1  oxysterol-binding protein-related protein 3 isoform X4

      UniProtKB/TrEMBL
      Q80UX3
      Conserved Domains (2) summary
      cd13287
      Location:30 → 127
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:363 → 707
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_030255599.2 → XP_030111459.1  oxysterol-binding protein-related protein 3 isoform X6

      Conserved Domains (1) summary
      pfam01237
      Location:127 → 471
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_006506631.5 → XP_006506694.1  oxysterol-binding protein-related protein 3 isoform X1

      UniProtKB/TrEMBL
      D3YTT6, Q80UX3
      Related
      ENSMUSP00000087473.4, ENSMUST00000090019.10
      Conserved Domains (2) summary
      cd13287
      Location:30 → 152
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:526 → 870
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_006506636.4 → XP_006506699.1  oxysterol-binding protein-related protein 3 isoform X5

      Conserved Domains (1) summary
      pfam01237
      Location:163 → 507
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBS9.2 GenPept UniProtKB/Swiss-Prot:Q9DBS9

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