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    Nacad NAC alpha domain containing [ Mus musculus (house mouse) ]

    Gene ID: 192950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nacadprovided by MGI
    Official Full Name
    NAC alpha domain containingprovided by MGI
    Primary source
    MGI:MGI:3603030
    See related
    Ensembl:ENSMUSG00000041073 AllianceGenome:MGI:3603030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0363; D230024G13Rik
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Is expressed in gut; nervous system; and sensory organ. Orthologous to human NACAD (NAC alpha domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 24.4), CNS E14 (RPKM 20.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nacad in Genome Data Viewer
    Location:
    11 A1; 11 4.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6547814..6556059, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6597814..6606059, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24000 Neighboring gene cerebral cavernous malformation 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:6481502-6481803 Neighboring gene transforming growth factor beta regulated gene 4 Neighboring gene predicted gene, 24313 Neighboring gene small nucleolar RNA, H/ACA box 5C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA0363

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAC-alpha domain-containing protein 1
    NP_001075121.1
    XP_036012341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081652.1 → NP_001075121.1  NAC-alpha domain-containing protein 1

      See identical proteins and their annotated locations for NP_001075121.1

      Status: VALIDATED

      Source sequence(s)
      BC072589
      Consensus CDS
      CCDS36108.1
      UniProtKB/Swiss-Prot
      Q5SWP3, Q6I6F5
      Related
      ENSMUSP00000049490.4, ENSMUST00000045713.4
      Conserved Domains (3) summary
      COG1308
      Location:1358 → 1504
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14416
      Location:1463 → 1504
      UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
      pfam01849
      Location:1359 → 1412
      NAC; NAC domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6547814..6556059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156448.1 → XP_036012341.1  NAC-alpha domain-containing protein 1 isoform X1

    RNA

    1. XR_380961.2 RNA Sequence

    2. XR_003949359.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SWP3.1 GenPept UniProtKB/Swiss-Prot:Q5SWP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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