Plscr3 phospholipid scramblase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plscr3provided by MGI
Official Full Name: phospholipid scramblase 3provided by MGI
Primary source: MGI:MGI:1917560
See related: Ensembl:ENSMUSG00000019461 AllianceGenome:MGI:1917560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ESTM3; 2210403O21Rik; 2610037N06Rik
Summary: Predicted to enable calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in apoptotic process and cellular response to lipopolysaccharide. Acts upstream of or within cholesterol homeostasis and glucose homeostasis. Located in mitochondrion and nucleus. Is expressed in ductus deferens; lower urinary tract; testis; and thyroid gland. Used to study obesity. Orthologous to human PLSCR3 (phospholipid scramblase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 35.8), limb E14.5 (RPKM 32.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.9 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69734937..69742884)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69846372..69852058)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that Scr3 functions as a negative regulator of adipogenesis in 3T3-L1 cells at a specific differentiation stage and that decrease in the intracellular amount of Scr3 protein caused by reduction in Scr3 mRNA expression
Title: Tubby-like protein superfamily member PLSCR3 functions as a negative regulator of adipogenesis in mouse 3T3-L1 preadipocytes by suppressing induction of late differentiation stage transcription factors.
expression of PLSCR3 may be required for normal adipocyte and/or macrophage maturation or function
Title: Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).
identified previously unrecognized lipid metabolites that suggest a novel molecular link between obesity, inflammation and the downstream consequences associated with PLSCR3-deficiency
Title: Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables lead ion binding	ISO Inferred from Sequence Orthology more info
enables lead ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables mercury ion binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid scramblase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane phospholipid scrambling	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipid scramblase 3

Names: Ca 2+ dependent phospholipid scramblase 3; PL scramblase 3; ca(2+)-dependent phospholipid scramblase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168497.1 → NP_001161969.1 phospholipid scramblase 3

See identical proteins and their annotated locations for NP_001161969.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK075841, AL603707

Consensus CDS

CCDS24916.1

UniProtKB/Swiss-Prot

Q9JIZ9

UniProtKB/TrEMBL

Q3T9B7, Q5F283

Related

ENSMUSP00000104272.2, ENSMUST00000108632.8

Conserved Domains (1) summary

pfam03803
Location:69 → 285

Scramblase
NM_023564.4 → NP_076053.1 phospholipid scramblase 3

See identical proteins and their annotated locations for NP_076053.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK011716, AL603707

Consensus CDS

CCDS24916.1

UniProtKB/Swiss-Prot

Q9JIZ9

UniProtKB/TrEMBL

Q3T9B7, Q5F283

Related

ENSMUSP00000104273.3, ENSMUST00000108633.9

Conserved Domains (1) summary

pfam03803
Location:69 → 285

Scramblase

RNA

NR_033133.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK029154, CJ166750