Slc25a21 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a21provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21provided by MGI
Primary source: MGI:MGI:2445059
See related: Ensembl:ENSMUSG00000035472 AllianceGenome:MGI:2445059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A630030I10; 9930033G19Rik
Summary: Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Located in mitochondrion. Is expressed in several structures, including genitourinary system; immune system; integumental system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 18. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14 (RPKM 5.7), liver E14.5 (RPKM 5.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 24.54 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (56759419..57244257, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (56712634..57197472, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of Slc25a21 is associated with orofacial defects and otitis media due to diminished expression of a neighboring gene, pax9.
Title: Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.
ODC-AS may promote lipid accumulation during adipocyte differentiation and play an important role in the regulation of lipid metabolism in adipose tissues. [ODS-AS]
Title: Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation
Transposon induced (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB158148 (e-PCR)
- UniSTS:185932

RH136125 (e-PCR)
- UniSTS:210120

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial alpha-ketoglutarate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial 2-oxodicarboxylate carrier

Names: mitochondrial solute carrier family 25 member 21; solute carrier family 25 member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167976.1 → NP_001161448.1 mitochondrial 2-oxodicarboxylate carrier isoform 2

See identical proteins and their annotated locations for NP_001161448.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, and encodes a longer isoform (2) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AK167535, EU180236

Consensus CDS

CCDS49069.1

UniProtKB/TrEMBL

B6CI26, Q3TRZ4

Related

ENSMUSP00000151751.2, ENSMUST00000217690.2

Conserved Domains (1) summary

pfam00153
Location:29 → 111

Mito_carr; Mitochondrial carrier protein
NM_172577.3 → NP_766165.2 mitochondrial 2-oxodicarboxylate carrier isoform 1

See identical proteins and their annotated locations for NP_766165.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

AK041694, AK162379, AK167535

Consensus CDS

CCDS25925.1

UniProtKB/Swiss-Prot

Q8BY72, Q8BZ09

UniProtKB/TrEMBL

Q3TRZ4

Related

ENSMUSP00000039289.6, ENSMUST00000044634.12

Conserved Domains (2) summary

PTZ00168
Location:11 → 280

PTZ00168; mitochondrial carrier protein; Provisional

pfam00153
Location:14 → 104

Mito_carr; Mitochondrial carrier protein