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    Mrgprb3 MAS-related GPR, member B3 [ Mus musculus (house mouse) ]

    Gene ID: 404238, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrgprb3provided by MGI
    Official Full Name
    MAS-related GPR, member B3provided by MGI
    Primary source
    MGI:MGI:3033117
    See related
    Ensembl:ENSMUSG00000070546 AllianceGenome:MGI:3033117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MrgB3
    Summary
    Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRX1 (MAS related GPR family member X1); MRGPRX2 (MAS related GPR family member X2); and MRGPRX3 (MAS related GPR family member X3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Mrgprb3 in Genome Data Viewer
    Location:
    7 B4; 7 31.11 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (48292611..48293549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (48642863..48643801, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member B9, pseudogene Neighboring gene MAS-related GPR, member B3 pseudogene Neighboring gene MAS-related GPR, member B11, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18886 Neighboring gene predicted gene 45086

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Han SK, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12397184, Free PMC Article
    2. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509
    3. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12909716, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member B3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207537.1 → NP_997420.1  mas-related G-protein coupled receptor member B3

      See identical proteins and their annotated locations for NP_997420.1

      Status: PROVISIONAL

      Source sequence(s)
      AY042201
      Consensus CDS
      CCDS21304.1
      UniProtKB/Swiss-Prot
      Q3B813, Q3B814, Q91ZC1
      UniProtKB/TrEMBL
      W8W3F6
      Related
      ENSMUSP00000091945.2, ENSMUST00000094383.3
      Conserved Domains (2) summary
      pfam00001
      Location:45 → 275
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 212
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      48292611..48293549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZC1.1 GenPept UniProtKB/Swiss-Prot:Q91ZC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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