Psmb2 proteasome (prosome, macropain) subunit, beta type 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmb2provided by MGI
Official Full Name: proteasome (prosome, macropain) subunit, beta type 2provided by MGI
Primary source: MGI:MGI:1347045
See related: Ensembl:ENSMUSG00000028837 AllianceGenome:MGI:1347045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C7-I; HC7-I; D4Wsu33e
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in embryo; extraembryonic component; and nucleus pulposus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 90.9), placenta adult (RPKM 89.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 60.9 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (126571460..126603503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126677637..126709715)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU045357 (e-PCR)
- UniSTS:159292

RH125718 (e-PCR)
- UniSTS:142500

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit beta type-2

Names: beta-4; macropain subunit C7-I; multicatalytic endopeptidase complex subunit C7-I; proteasome component C7-I; proteasome subunit beta-4

NP_001411865.1

EC 3.4.25.1

NP_036100.3

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424936.1 → NP_001411865.1 proteasome subunit beta type-2 isoform 2

Status: VALIDATED

Source sequence(s)

AL607129
NM_011970.5 → NP_036100.3 proteasome subunit beta type-2 isoform 1

See identical proteins and their annotated locations for NP_036100.3

Status: VALIDATED

Source sequence(s)

AL607129

Consensus CDS

CCDS18657.1

UniProtKB/Swiss-Prot

Q9R1P3

UniProtKB/TrEMBL

Q8BJX0

Related

ENSMUSP00000030642.3, ENSMUST00000030642.3

Conserved Domains (1) summary

cd03758
Location:1 → 192

proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...