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    Atp5pb ATP synthase peripheral stalk-membrane subunit b [ Mus musculus (house mouse) ]

    Gene ID: 11950, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp5pbprovided by MGI
    Official Full Name
    ATP synthase peripheral stalk-membrane subunit bprovided by MGI
    Primary source
    MGI:MGI:1100495
    See related
    Ensembl:ENSMUSG00000000563 AllianceGenome:MGI:1100495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5f1
    Summary
    Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 196.9), heart adult (RPKM 162.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp5pb in Genome Data Viewer
    Location:
    3 F2.2; 3 46.46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105850014..105866579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105942698..105959263, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E9567 Neighboring gene adenosine A3 receptor Neighboring gene RIKEN cDNA I830077J02 gene Neighboring gene STARR-seq mESC enhancer starr_08641 Neighboring gene WD repeat domain 77 Neighboring gene oviductal glycoprotein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. Lehman JJ, et al. J Clin Invest, 2000 Oct. PMID 11018072, Free PMC Article
    2. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. Ruan QT, et al. J Neurosci, 2020 Jan 2. PMID 31704785, Free PMC Article
    3. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Babalola GO, et al. Mol Reprod Dev, 1995 Jun. PMID 7654366
    4. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
    5. Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Piazzi M, et al. Mol Cell Proteomics, 2013 Aug. PMID 23665500, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit B1, mitochondrial
    Names
    ATP synthase subunit b, mitochondrial
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
    ATPase subunit b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304719.2 → NP_001291648.1  ATP synthase F(0) complex subunit B1, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' region and uses an alternate start codon compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC025786
      UniProtKB/TrEMBL
      Q3TJD4, Q3UF04
      Conserved Domains (1) summary
      pfam05405
      Location:58 → 219
      Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

    2. NM_009725.5 → NP_033855.2  ATP synthase F(0) complex subunit B1, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_033855.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC025786
      Consensus CDS
      CCDS17714.1
      UniProtKB/Swiss-Prot
      Q9CQQ7
      UniProtKB/TrEMBL
      Q3TJD4, Q3UF04, Q5I0W0
      Related
      ENSMUSP00000113022.2, ENSMUST00000118209.8
      Conserved Domains (1) summary
      pfam05405
      Location:83 → 244
      Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105850014..105866579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQQ7.1 GenPept UniProtKB/Swiss-Prot:Q9CQQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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