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    Wdr31 WD repeat domain 31 [ Mus musculus (house mouse) ]

    Gene ID: 71354, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wdr31provided by MGI
    Official Full Name
    WD repeat domain 31provided by MGI
    Primary source
    MGI:MGI:1918604
    See related
    Ensembl:ENSMUSG00000028391 AllianceGenome:MGI:1918604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    spWD; 5430402I10Rik
    Summary
    Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; genitourinary system; lung; and olfactory epithelium. Orthologous to human WDR31 (WD repeat domain 31). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 27.3), kidney adult (RPKM 1.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Wdr31 in Genome Data Viewer
    Location:
    4 B3; 4 33.14 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62366890..62389236, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62448653..62470999, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene pre-mRNA processing factor 4 Neighboring gene ring finger protein 183 Neighboring gene predicted gene, 30589 Neighboring gene B-box and SPRY domain containing Neighboring gene haloacid dehalogenase-like hydrolase domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential display to identify and isolate novel genes expressed during spermatogenesis. Catalano RD, et al. Mol Hum Reprod, 1997 Mar. PMID 9237247
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 31
    Names
    spermatid WD repeat-containing protein
    spermatid WD-repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290521.2 → NP_001277450.1  WD repeat-containing protein 31 isoform 1

      See identical proteins and their annotated locations for NP_001277450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK141026, AL732594, CK618879
      Consensus CDS
      CCDS18240.1
      UniProtKB/Swiss-Prot
      Q3URZ0, Q9D3N4, Q9JHB4
      Related
      ENSMUSP00000112719.2, ENSMUST00000120095.8
      Conserved Domains (2) summary
      cd00200
      Location:61 → 344
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:65 → 101
      7WD40; WD40 repeat [structural motif]

    2. NM_001290522.2 → NP_001277451.1  WD repeat-containing protein 31 isoform 2

      See identical proteins and their annotated locations for NP_001277451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AK017259, AK141026, AL732594, CK618879
      Consensus CDS
      CCDS71402.1
      UniProtKB/Swiss-Prot
      Q9JHB4
      Related
      ENSMUSP00000103076.2, ENSMUST00000107452.8
      Conserved Domains (3) summary
      COG2319
      Location:60 → 342
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:60 → 343
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:64 → 100
      7WD40; WD40 repeat [structural motif]

    3. NM_001355523.1 → NP_001342452.1  WD repeat-containing protein 31 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, compared to variant 1, which results in a translational framshift It encodes isoform 3 which has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK017259, AK141026, AL732594, AV039764, CK618879
      Conserved Domains (2) summary
      sd00039
      Location:66 → 101
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61 → 250
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_023597.3 → NP_076086.1  WD repeat-containing protein 31 isoform 1

      See identical proteins and their annotated locations for NP_076086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK017259, AK141026, AL732594, CK618879
      Consensus CDS
      CCDS18240.1
      UniProtKB/Swiss-Prot
      Q3URZ0, Q9D3N4, Q9JHB4
      Related
      ENSMUSP00000030087.8, ENSMUST00000030087.14
      Conserved Domains (2) summary
      cd00200
      Location:61 → 344
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:65 → 101
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62366890..62389236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538257.4 → XP_006538320.1  WD repeat-containing protein 31 isoform X2

      Related
      ENSMUST00000146108.8
      Conserved Domains (2) summary
      cd00200
      Location:61 → 316
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:65 → 101
      7WD40; WD40 repeat [structural motif]

    2. XM_006538259.4 → XP_006538322.1  WD repeat-containing protein 31 isoform X4

      See identical proteins and their annotated locations for XP_006538322.1

      Conserved Domains (2) summary
      sd00039
      Location:66 → 101
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61 → 250
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006538258.4 → XP_006538321.1  WD repeat-containing protein 31 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:66 → 101
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61 → 215
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_036164428.1 → XP_036020321.1  WD repeat-containing protein 31 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:66 → 101
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61 → 215
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_030253780.2 → XP_030109640.1  WD repeat-containing protein 31 isoform X5

      Conserved Domains (2) summary
      sd00039
      Location:65 → 100
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:60 → 249
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_006538254.3 → XP_006538317.1  WD repeat-containing protein 31 isoform X1

      See identical proteins and their annotated locations for XP_006538317.1

      UniProtKB/Swiss-Prot
      Q3URZ0, Q9D3N4, Q9JHB4
      Conserved Domains (2) summary
      cd00200
      Location:61 → 344
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:65 → 101
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_004941962.1 RNA Sequence

    2. XR_390342.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHB4.1 GenPept UniProtKB/Swiss-Prot:Q9JHB4

    Gene LinkOut

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