Lpxn leupaxin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpxnprovided by MGI
Official Full Name: leupaxinprovided by MGI
Primary source: MGI:MGI:2147677
See related: Ensembl:ENSMUSG00000024696 AllianceGenome:MGI:2147677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LDPL; 4933402K05Rik; A530083L21Rik
Summary: Enables transcription coregulator activity. Involved in negative regulation of B cell receptor signaling pathway and regulation of cell adhesion mediated by integrin. Located in focal adhesion; nucleus; and podosome. Is expressed in central nervous system; genitourinary system; and thymus. Orthologous to human LPXN (leupaxin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 12.1), thymus adult (RPKM 11.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.73 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (12773251..12811177)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (12795887..12833813)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leupaxin Expression Is Dispensable for B Cell Immune Responses.
Title: Leupaxin Expression Is Dispensable for B Cell Immune Responses.
The kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling.
Title: A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling.
Title: LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.
Title: The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.
Leupaxin plays an inhibitory role in BCR signaling and B cell function.
Title: Leupaxin negatively regulates B cell receptor signaling.
leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex
Title: Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast.
Association of the scaffold protein LPXN with Src adds further complexity to the organization of the podosomal signaling complex in osteoclasts.
Title: Association of leupaxin with Src in osteoclasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lpxn (e-PCR), detects polymorphism
- UniSTS:536531

AV278559 (e-PCR)
- UniSTS:181209

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leupaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361971.1 → NP_001348900.1 leupaxin isoform 2

Status: VALIDATED

Source sequence(s)

AK077085, AV257675

Consensus CDS

CCDS89350.1

UniProtKB/TrEMBL

A0A494B990

Related

ENSMUSP00000157548.2, ENSMUST00000235690.2

Conserved Domains (2) summary

cd09339
Location:233 → 284

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

cl02475
Location:54 → 108

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_134152.4 → NP_598913.1 leupaxin isoform 1

See identical proteins and their annotated locations for NP_598913.1

Status: VALIDATED

Source sequence(s)

AC135633, AC150901

Consensus CDS

CCDS29638.1

UniProtKB/Swiss-Prot

Q99N69

UniProtKB/TrEMBL

Q8R355

Related

ENSMUSP00000025601.7, ENSMUST00000025601.8

Conserved Domains (2) summary

cd09339
Location:329 → 380

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

cl02475
Location:150 → 204

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

12773251..12811177

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250687.1 → XP_030106547.1 leupaxin isoform X1

UniProtKB/TrEMBL

A0A494B990

Conserved Domains (2) summary

cd09339
Location:233 → 284

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

cl02475
Location:54 → 108

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_030250689.2 → XP_030106549.1 leupaxin isoform X1

UniProtKB/TrEMBL

A0A494B990

Conserved Domains (2) summary

cd09339
Location:233 → 284

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

cl02475
Location:54 → 108

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_030250688.2 → XP_030106548.1 leupaxin isoform X1

UniProtKB/TrEMBL

A0A494B990

Conserved Domains (2) summary

cd09339
Location:233 → 284

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

cl02475
Location:54 → 108

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers