Tnfaip8l1 tumor necrosis factor, alpha-induced protein 8-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfaip8l1provided by MGI
Official Full Name: tumor necrosis factor, alpha-induced protein 8-like 1provided by MGI
Primary source: MGI:MGI:1913693
See related: Ensembl:ENSMUSG00000044469 AllianceGenome:MGI:1913693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIPE1; 2600017J23Rik
Summary: Predicted to enable identical protein binding activity. Involved in negative regulation of TOR signaling. Located in cytoplasm. Orthologous to human TNFAIP8L1 (TNF alpha induced protein 8 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver adult (RPKM 8.7), thymus adult (RPKM 7.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 29.19 cM; 17 D

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (56469439..56491249)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (56162439..56184249)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIPE1 limits virus replication by disrupting PKM2/ HIF-1alpha/ glycolysis feedback loop.
Title: TIPE1 limits virus replication by disrupting PKM2/ HIF-1α/ glycolysis feedback loop.
Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation.
Title: Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation.
TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
Title: TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
Title: TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
Title: TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
TIPE1(TNFAIP8-like 1)protein was detected in a variety of tissues such as neurons, brain, hepatocytes, germ cells of female and male reproductive organs, muscular tissues and cells of epithelial origin it was not expressed in mature T or B lymphocytes
Title: The expression of TIPE1 in murine tissues and human cell lines.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 8-like protein 1

Names: TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; oxidative stress regulated gene-beta; oxy-beta; tumor necrosis factor, alpha-induced protein 8-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025566.3 → NP_079842.2 tumor necrosis factor alpha-induced protein 8-like protein 1

See identical proteins and their annotated locations for NP_079842.2

Status: VALIDATED

Source sequence(s)

AK136962, BY733616

Consensus CDS

CCDS28897.1

UniProtKB/Swiss-Prot

Q3U6E5, Q8K288, Q9D0N6, Q9DBH7

Related

ENSMUSP00000076961.7, ENSMUST00000077788.7

Conserved Domains (1) summary

pfam05527
Location:25 → 177

DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

56469439..56491249

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160743.1 → XP_036016636.1 tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3U6E5, Q8K288, Q9D0N6, Q9DBH7

Conserved Domains (1) summary

pfam05527
Location:25 → 177

DUF758; Domain of unknown function (DUF758)
XM_030249985.1 → XP_030105845.1 tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

UniProtKB/Swiss-Prot

Q3U6E5, Q8K288, Q9D0N6, Q9DBH7

Conserved Domains (1) summary

pfam05527
Location:25 → 177

DUF758; Domain of unknown function (DUF758)