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    Slc35a3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 229782, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc35a3provided by MGI
    Official Full Name
    solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3provided by MGI
    Primary source
    MGI:MGI:1917648
    See related
    Ensembl:ENSMUSG00000027957 AllianceGenome:MGI:1917648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310050P13Rik
    Summary
    Enables UDP-galactose transmembrane transporter activity. Involved in UDP-N-acetylglucosamine transmembrane transport. Predicted to be active in Golgi membrane. Is expressed in several structures, including limb; metanephros; tail; testis; and trunk. Orthologous to human SLC35A3 (solute carrier family 35 member A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 5.1), colon adult (RPKM 4.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35a3 in Genome Data Viewer
    Location:
    3 G1; 3 50.44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116463118..116506366, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116669469..116712708, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SAS-6 centriolar assembly protein Neighboring gene STARR-seq mESC enhancer starr_08785 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene STARR-positive B cell enhancer ABC_E3464 Neighboring gene STARR-seq mESC enhancer starr_08789 Neighboring gene STARR-seq mESC enhancer starr_08790 Neighboring gene microRNA 3473h Neighboring gene predicted gene, 40126 Neighboring gene predicted gene, 54181 Neighboring gene STARR-seq mESC enhancer starr_08794 Neighboring gene amylo-1,6-glucosidase, 4-alpha-glucanotransferase Neighboring gene STARR-positive B cell enhancer ABC_E4582 Neighboring gene predicted gene, 40128

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3. Toscanini MA, et al. J Biol Chem, 2019 Jun 28. PMID 31118275, Free PMC Article
    2. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. Saito S, et al. PLoS One, 2023. PMID 37053259, Free PMC Article
    3. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. O'Shaughnessy PJ, et al. Endocrinology, 2007 Jun. PMID 17332066
    4. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
    5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
      Title: Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
    2. cells expressing E47C or K50C mSlc35a3 variants had lower levels of GlcNAc-containing glycoconjugates than WT cells
      Title: Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UDP-galactose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine transporter
    Names
    golgi UDP-GlcNAc transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362374.2 → NP_001349303.1  UDP-N-acetylglucosamine transporter isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242
      Consensus CDS
      CCDS17791.1
      UniProtKB/Swiss-Prot
      Q8BRW7, Q8R1T4
      UniProtKB/TrEMBL
      Q3TTK5
      Related
      ENSMUSP00000112674.2, ENSMUST00000120120.8
      Conserved Domains (1) summary
      pfam04142
      Location:1 → 314
      Nuc_sug_transp; Nucleotide-sugar transporter

    2. NM_001404697.1 → NP_001391626.1  UDP-N-acetylglucosamine transporter isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    3. NM_001404698.1 → NP_001391627.1  UDP-N-acetylglucosamine transporter isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242
      UniProtKB/Swiss-Prot
      Q8BRW7, Q8R1T4

    4. NM_001404699.1 → NP_001391628.1  UDP-N-acetylglucosamine transporter isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    5. NM_001404700.1 → NP_001391629.1  UDP-N-acetylglucosamine transporter isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    6. NM_001404701.1 → NP_001391630.1  UDP-N-acetylglucosamine transporter isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    7. NM_001404702.1 → NP_001391631.1  UDP-N-acetylglucosamine transporter isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    8. NM_001404703.1 → NP_001391632.1  UDP-N-acetylglucosamine transporter isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    9. NM_001404704.1 → NP_001391633.1  UDP-N-acetylglucosamine transporter isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    10. NM_144902.5 → NP_659151.1  UDP-N-acetylglucosamine transporter isoform 1

      See identical proteins and their annotated locations for NP_659151.1

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242
      Consensus CDS
      CCDS17791.1
      UniProtKB/Swiss-Prot
      Q8BRW7, Q8R1T4
      UniProtKB/TrEMBL
      Q3TTK5
      Related
      ENSMUSP00000029569.3, ENSMUST00000029569.9
      Conserved Domains (1) summary
      pfam04142
      Location:1 → 314
      Nuc_sug_transp; Nucleotide-sugar transporter

    RNA

    1. NR_175853.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    2. NR_175854.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131038, AC147242

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      116463118..116506366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163085.1 → XP_036018978.1  UDP-N-acetylglucosamine transporter isoform X5

      Conserved Domains (1) summary
      pfam04142
      Location:1 → 233
      Nuc_sug_transp; Nucleotide-sugar transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1T4.1 GenPept UniProtKB/Swiss-Prot:Q8R1T4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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