Rxfp2 relaxin/insulin-like family peptide receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rxfp2provided by MGI
Official Full Name: relaxin/insulin-like family peptide receptor 2provided by MGI
Primary source: MGI:MGI:2153463
See related: Ensembl:ENSMUSG00000053368 AllianceGenome:MGI:2153463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lgr8; Great; Gpr106
Summary: Enables protein-hormone receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and male gonad development. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; and peritoneum. Used to study cryptorchidism. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 1.6), subcutaneous fat pad adult (RPKM 1.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 89.23 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (149941487..150006015)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (150018675..150082550)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of function of Lgr6 did not impact epidermal cell proliferation, cell migration and wound healing.
Title: Lgr6 is dispensable for epidermal cell proliferation and wound repair.
Results suggest that DES causes testicular maldescent by altering the LGR8 pathway in mouse gubernaculum testis cells.
Title: Diethylstilbestrol Regulates the Expression of LGR8 in Mouse Gubernaculum Testis Cells.
The results displayed that INSL3 changed RXFP2 expression in mouse gubernaculum testis cells in vitro
Title: An insight into insulin-like factor 3 regulate its receptor RXFP2 in mouse gubernaculum testis cells.
data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2
Title: RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro.
Rxfp1, Rxfp2, and Nr3c1 mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
Title: Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice.
Spermatogonial stem cells undergo drastic depletion in the cryptorchid testes of RXFP2 deficient mice.
Title: The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice.
Data suggest that Insl3/Rxfp2 (insulin-like peptide 3/relaxin receptor 2) signaling is important for testicular descent; however, germ-cell deletion of Rxfp2 did not affect spermatogenesis, germ cell survival, or male fertility.
Title: Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.
Prenatal exposure to diethylstilbestrol increased the expression of LGR8 mRNA in the mouse gubernaculum testis.
Title: [Diethylstilbestrol affects LGR8 expression in mouse gubernaculum testis].
A deficiency for Rxfp2 on Cav1-deficient background led to more than a 2-fold increase in the incidence of uterine cysts.
Title: Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2.
A mouse model was created containing a novel missense mutation in Relaxin/insulin-like family peptide receptor 2 which likely prevents binding to its ligand, Insulin-like peptide 3, resulting in failure of the transabdominal phase of testicular descent.
Title: A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpr106 (e-PCR), detects polymorphism
- UniSTS:234014

NoName (e-PCR)
- UniSTS:224604

Rxfp2 (e-PCR), detects polymorphism
- UniSTS:527529

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein-hormone receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: relaxin receptor 2

Names: G protein coupled receptor affecting testicular descent; G protein-coupled receptor 106; leucine-rich repeat-containing G protein-coupled receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289564.1 → NP_001276493.1 relaxin receptor 2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AF346501, AK039086, BC144802, BM249687

Consensus CDS

CCDS80480.1

UniProtKB/TrEMBL

B7ZMU5, E9Q0U9

Related

ENSMUSP00000106122.2, ENSMUST00000110496.5

Conserved Domains (6) summary

cd00112
Location:28 → 63

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:163 → 319

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:122 → 145

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:391 → 650

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:144 → 204

LRR_8; Leucine rich repeat

cl21561
Location:383 → 602

7tm_4; Olfactory receptor
NM_001289566.1 → NP_001276495.1 relaxin receptor 2 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC077689, AF346501, AK039086, BC144802, BM249687

Consensus CDS

CCDS80479.1

UniProtKB/TrEMBL

A0A0J9YV81, B7ZMU6

Related

ENSMUSP00000144536.2, ENSMUST00000201612.2

Conserved Domains (7) summary

cd00112
Location:28 → 63

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:163 → 333

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:122 → 145

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:405 → 664

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12799
Location:144 → 185

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:144 → 201

LRR_8; Leucine rich repeat

cl21561
Location:397 → 534

7tm_4; Olfactory receptor
NM_080468.2 → NP_536716.2 relaxin receptor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_536716.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF346501, AK039086, BC120741, CJ243198

Consensus CDS

CCDS19886.1

UniProtKB/Swiss-Prot

Q0VB90, Q91ZZ5

UniProtKB/TrEMBL

B7ZMU5

Related

ENSMUSP00000067897.4, ENSMUST00000065745.10

Conserved Domains (6) summary

cd00112
Location:28 → 63

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:163 → 322

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:122 → 145

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:415 → 674

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:144 → 204

LRR_8; Leucine rich repeat

cl21561
Location:407 → 626

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

149941487..150006015

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164780.1 → XP_036020673.1 relaxin receptor 2 isoform X3

UniProtKB/TrEMBL

B7ZMU5

Conserved Domains (5) summary

cd00112
Location:28 → 63

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:96 → 119

LRR_RI; leucine-rich repeat [structural motif]

cd14964
Location:374 → 400

7tm_GPCRs; TM helix 1 [structural motif]

cd21340
Location:95 → 316

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl28897
Location:374 → 659

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011241023.4 → XP_011239325.1 relaxin receptor 2 isoform X5

Conserved Domains (3) summary

cd00112
Location:31 → 66

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:125 → 148

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:148 → 207

LRR_8; Leucine rich repeat
XM_011241022.2 → XP_011239324.1 relaxin receptor 2 isoform X2

UniProtKB/TrEMBL

B7ZMU5

Conserved Domains (6) summary

COG4886
Location:78 → 327

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00112
Location:31 → 66

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:99 → 122

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:122 → 181

LRR_8; Leucine rich repeat

cd14964
Location:377 → 403

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:377 → 662

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011241021.3 → XP_011239323.1 relaxin receptor 2 isoform X1

UniProtKB/TrEMBL

B7ZMU5

Conserved Domains (6) summary

COG4886
Location:104 → 353

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00112
Location:31 → 66

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:125 → 148

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:148 → 207

LRR_8; Leucine rich repeat

cd14964
Location:403 → 429

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:403 → 688

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006504911.5 → XP_006504974.1 relaxin receptor 2 isoform X4

Conserved Domains (4) summary

COG4886
Location:90 → 292

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:92 → 111

LRR_RI; leucine-rich repeat [structural motif]

cd14964
Location:342 → 368

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:342 → 627

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily